A Single Fluorescent Probe to Visualize Hydrogen Sulfide and Hydrogen Polysulfides with Different Fluorescence Signals

被引：272

作者：

Chen, Wei ^{[1
]}

Pacheco, Armando ^{[1
]}

Takano, Yoko ^{[2
]}

Day, Jacob J. ^{[1
]}

Hanaoka, Kenjiro ^{[2
]}

Xian, Ming ^{[1
]}

机构：

[1] Washington State Univ, Dept Chem, Pullman, WA 99164 USA

[2] Univ Tokyo, Grad Sch Pharmaceut Sci, Tokyo 1130033, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 34期

关键词：

cyclization; fluorescence; fluorescent probes; hydrogen polysulfides; sulfides; BIOIMAGING APPLICATIONS; CYSTEINE PERSULFIDES; BIOLOGICAL-SYSTEMS; S-SULFHYDRATION; RATIONAL DESIGN; IN-VIVO; CHEMISTRY; H2S; STRATEGY; STRESS;

D O I：

10.1002/anie.201604892

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hydrogen sulfide (H2S) and hydrogen polysulfides (H2Sn, n>1) are endogenous regulators of many physiological processes. In order to better understand the symbiotic relationship and cellular cross-talk between H2S and H2Sn, it is highly desirable to develop single fluorescent probes which enable dual-channel discrimination between H2S and H2Sn. Herein, we report the rational design, synthesis, and evaluation of the first dual-detection fluorescent probe DDP-1 that can visualize H2S and H2Sn with different fluorescence signals. The probe showed high selectivity and sensitivity to H2S and H2Sn in aqueous media and in cells.

引用

页码：9993 / 9996

页数：4

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