A Single Fluorescent Probe to Visualize Hydrogen Sulfide and Hydrogen Polysulfides with Different Fluorescence Signals

被引：270
|
作者：
Chen, Wei [1 ]
Pacheco, Armando [1 ]
Takano, Yoko [2 ]
Day, Jacob J. [1 ]
Hanaoka, Kenjiro [2 ]
Xian, Ming [1 ]
机构：
[1] Washington State Univ, Dept Chem, Pullman, WA 99164 USA
[2] Univ Tokyo, Grad Sch Pharmaceut Sci, Tokyo 1130033, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 34期
关键词：
cyclization; fluorescence; fluorescent probes; hydrogen polysulfides; sulfides; BIOIMAGING APPLICATIONS; CYSTEINE PERSULFIDES; BIOLOGICAL-SYSTEMS; S-SULFHYDRATION; RATIONAL DESIGN; IN-VIVO; CHEMISTRY; H2S; STRATEGY; STRESS;
D O I：
10.1002/anie.201604892
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Hydrogen sulfide (H2S) and hydrogen polysulfides (H2Sn, n>1) are endogenous regulators of many physiological processes. In order to better understand the symbiotic relationship and cellular cross-talk between H2S and H2Sn, it is highly desirable to develop single fluorescent probes which enable dual-channel discrimination between H2S and H2Sn. Herein, we report the rational design, synthesis, and evaluation of the first dual-detection fluorescent probe DDP-1 that can visualize H2S and H2Sn with different fluorescence signals. The probe showed high selectivity and sensitivity to H2S and H2Sn in aqueous media and in cells.
引用
收藏
页码：9993 / 9996
页数：4
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