The Developmental History of the Gadolinium Chelates as Intravenous Contrast Media for Magnetic Resonance

被引：38

作者：

Runge, Val M. ^{[1
]}

Ai, Tao ^{[2
]}

Hao, Dapeng ^{[3
]}

Hu, Xuemei ^{[2
]}

机构：

[1] Univ Texas Med Branch, Dept Radiol, Galveston, TX 77555 USA

[2] Huazhong Univ Sci & Technol, Dept Radiol, Tongji Hosp, Tongji Med Coll, Wuhan 430074, Peoples R China

[3] Qingdao Univ, Dept Radiol, Affiliated Hosp, Coll Med, Qingdao 266071, Peoples R China

来源：

INVESTIGATIVE RADIOLOGY | 2011年 / 46卷 / 12期

关键词：

gadolinium; magnetic resonance (MR); intravenous contrast media; NEPHROGENIC SYSTEMIC FIBROSIS; GD-EOB-DTPA; BRAIN-TUMOR ENHANCEMENT; HUMAN SKIN FIBROBLASTS; MAGNEVIST GADOPENTETATE DIMEGLUMINE; CENTRAL-NERVOUS-SYSTEM; HIGH-DOSE GADOTERIDOL; FOCAL LIVER-LESIONS; III CLINICAL-TRIAL; HUMAN BLOOD-PLASMA;

D O I：

10.1097/RLI.0b013e318237913b

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The developmental history of the gadolinium chelates, which spans 30 years, is described, focusing, in part, on the seminal work with each of the major agents in use today. By examining this history, insight is gained into important issues of efficacy and safety, with valuable lessons to be learned from the mistakes made during this period. An overview of physicochemical characteristics and chemical structures is also provided. The review concludes with a discussion of current research directions involving this field, which is that of the intravenous contrast media for magnetic resonance, in the past 5 years.

引用

页码：807 / 816

页数：10

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