MicroRNAs in colorectal cancer: Function, dysregulation and potential as novel biomarkers

被引：53

作者：

Nugent, M. ^{[1
]}

Miller, N. ^{[1
]}

Kerin, M. J. ^{[1
]}

机构：

[1] Natl Univ Ireland, Galway, Ireland

来源：

EJSO | 2011年 / 37卷 / 08期

关键词：

Colorectal; Cancer; microRNA; Biomarkers; HUMAN COLON-CANCER; MICROSATELLITE INSTABILITY; CIRCULATING MICRORNAS; GENE-EXPRESSION; INVASION; P53; SUPPRESSION; METASTASIS; MARKERS; STAGE;

D O I：

10.1016/j.ejso.2011.05.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: MicroRNAs (miRNAs) are short non-coding segments of RNA which are involved in normal cellular development and proliferation. Recent studies have identified altered miRNA expression in both tumour tissues and circulation in the presence of colorectal cancer. These altered expression patterns may serve as novel biomarkers for colorectal cancer. This review explores recent developments in this rapidly evolving field. Methods: A thorough literature search was performed to identify studies describing miRNA expression in colorectal cancer. Specific areas of interest included miRNA expression patterns in relation to development, diagnosis, progression and recurrence of disease, and potential future therapeutic applications. Results: MiRNAs are associated with the development and progression of colorectal cancer. These may be either overexpressed or underexpressed (depending on the specific miRNA). Although there are fewer published studies regarding circulating miRNAs, these appear to be reflective of alterations in tissue expression and may have a potential role as minimally invasive biomarkers. Conclusion: MiRNAs have immense potential for refinement of the current processes for diagnosis, staging and prognostic prediction. They may also provide potential future therapeutic targets in the management of colorectal cancer. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：649 / 654

页数：6

共 49 条

[1]

Ahmed Farid E., 2009, Cancer Genomics & Proteomics, V6, P281

[2] Characterization of global microRNA expression reveals oncogenic potential of miR-145 in metastatic colorectal cancer [J].

Arndt, Greg M. ;

Dossey, Lesley ;

Cullen, Lara M. ;

Lai, Angela ;

Druker, Riki ;

Eisbacher, Michael ;

Zhang, Chunyan ;

Tran, Nham ;

Fan, Hongtao ;

Retzlaff, Kathy ;

Bittner, Anton ;

Raponi, Mitch .

BMC CANCER, 2009, 9 :374

[3] MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer [J].

Asangani, I. A. ;

Rasheed, S. A. K. ;

Nikolova, D. A. ;

Leupold, J. H. ;

Colburn, N. H. ;

Post, S. ;

Allgayer, H. .

ONCOGENE, 2008, 27 (15) :2128-2136

[4] Identification by Real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues [J].

Bandres, E. ;

Cubedo, E. ;

Agirre, X. ;

Malumbres, R. ;

Zarate, R. ;

Ramirez, N. ;

Abajo, A. ;

Navarro, A. ;

Moreno, I. ;

Monzo, M. ;

Garcia-Foncillas, J. .

MOLECULAR CANCER, 2006, 5 (1)

[5] Epigenetic regulation of microRNA expression in colorectal cancer [J].

Bandres, Eva ;

Agirre, Xabier ;

Bitarte, Nerea ;

Ramirez, Natalia ;

Zarate, Ruth ;

Roman-Gomez, Jose ;

Prosper, Felipe ;

Garcia-Foncillas, Jesus .

INTERNATIONAL JOURNAL OF CANCER, 2009, 125 (11) :2737-2743

[6] MicroRNA expression profiling to identify and validate reference genes for relative quantification in colorectal cancer [J].

Chang, Kah Hoong ;

Mestdagh, Pieter ;

Vandesompele, Jo ;

Kerin, Michael J. ;

Miller, Nicola .

BMC CANCER, 2010, 10

[7] Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis [J].

Chang, Tsung-Cheng ;

Wentzel, Erik A. ;

Kent, Oliver A. ;

Ramachandran, Kalyani ;

Mullendore, Michael ;

Lee, Kwang Hyuck ;

Feldmann, Georg ;

Yamakuchi, Munekazu ;

Ferlito, Marcella ;

Lowenstein, Charles J. ;

Arking, Dan E. ;

Beer, Michael A. ;

Maitra, Anirban ;

Mendell, Joshua T. .

MOLECULAR CELL, 2007, 26 (05) :745-752

[8] Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases [J].

Chen, Xi ;

Ba, Yi ;

Ma, Lijia ;

Cai, Xing ;

Yin, Yuan ;

Wang, Kehui ;

Guo, Jigang ;

Zhang, Yujing ;

Chen, Jiangning ;

Guo, Xing ;

Li, Qibin ;

Li, Xiaoying ;

Wang, Wenjing ;

Zhang, Yan ;

Wang, Jin ;

Jiang, Xueyuan ;

Xiang, Yang ;

Xu, Chen ;

Zheng, Pingping ;

Zhang, Juanbin ;

Li, Ruiqiang ;

Zhang, Hongjie ;

Shang, Xiaobin ;

Gong, Ting ;

Ning, Guang ;

Wang, Jun ;

Zen, Ke ;

Zhang, Junfeng ;

Zhang, Chen-Yu .

CELL RESEARCH, 2008, 18 (10) :997-1006

[9] Implications of micro-RNA profiling for cancer diagnosis [J].

Cummins, J. M. ;

Velculescu, V. E. .

ONCOGENE, 2006, 25 (46) :6220-6227

[10] The colorectal microRNAome [J].

Cummins, JM ;

He, YP ;

Leary, RJ ;

Pagliarini, R ;

Diaz, LA ;

Sjoblom, T ;

Barad, O ;

Bentwich, Z ;

Szafranska, AE ;

Labourier, E ;

Raymond, CK ;

Roberts, BS ;

Juhl, H ;

Kinzler, KW ;

Vogelstein, B ;

Velculescu, VE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (10) :3687-3692

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