Ruthenium(III) chloride-catalyzed one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions

被引：96

作者：

De, SK ^{[1
]}

Gibbs, RA ^{[1
]}

机构：

[1] Purdue Univ, Sch Pharm, Purdue Canc Ctr, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA

来源：

SYNTHESIS-STUTTGART | 2005年 / 11期

关键词：

pyrimidinones; ruthenium; aldehyde; Biginelli reaction; solvent-free conditions; heterocycles;

D O I：

10.1055/s-2005-869899

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ruthenium(III) chloride efficiently catalyzes the three-component Biginelli reaction of an aldehyde, a beta-keto ester, and urea or thiourea under solvent-free conditions to afford the corresponding 3,4-dihydropyrimidine-2-(1H)-ones in excellent yields.

引用

页码：1748 / 1750

页数：3

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