Toxicological and Genotoxicity Assessment of a Dihydroquercetin-Rich Dahurian Larch Tree (Larix gmelinii Rupr) Extract (Lavitol)

被引：43

作者：

Schauss, Alexander G. ^{[1
]}

Tselyico, Sergei S. ^{[2
]}

Kuznetsova, Victoria A. ^{[3
]}

Yegorova, Inna ^{[4
]}

机构：

[1] AIBMR Life Sci, Nat & Med Prod Res, Puyallup, WA 98373 USA

[2] Amur State Med Univ, Dept Morphol, Cent Res Lab, Blagoveshchensk, Amur Oblast, Russia

[3] JSC, Ametis, Blagoveshchensk, Amur Oblast, Russia

[4] Inna Consulting Serv, Northridge, CA USA

来源：

INTERNATIONAL JOURNAL OF TOXICOLOGY | 2015年 / 34卷 / 02期

关键词：

Larix gmelinii; Larix dahurica; dihydroquercetin; taxifolin; Dahurian larch tree extract; antioxidant; flavonoid; food additive; dietary supplement; comet assay; chromosomal aberration test; micronucleus test; acute toxicity study; subchronic toxicity study; developmental toxicity study; ZERO DOSE CONTROL; MICRONUCLEI; LYMPHOCYTES;

D O I：

10.1177/1091581815576975

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Safety assessment is reported of an orally ingested dihydroquercetin-rich extract (Lavitol) derived from the Dahurian larch tree, used as a food additive and as a dietary supplement ingredient. Dihydroquercetin, a potent antioxidant, is also known as taxifolin. The results of genotoxicity and toxicological tests (Comet assay, micronucleus test in human lymphocytes, chromosomal aberration test, subacute 7-day oral toxicity study, subchronic 90-day toxicology study with histopathologies, and, prenatal and postnatal developmental toxicity studies) on the extract provide further support for the safety of its consumption as a food supplement and food additive.

引用

页码：162 / 181

页数：20

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