Recombinant Cytokines from Plants

被引：27

作者：

Sirko, Agnieszka ^{[1
]}

Vanek, Tomas ^{[2
]}

Gora-Sochacka, Anna ^{[1
]}

Redkiewicz, Patrycja ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Biochem & Biophys, PL-02106 Warsaw, Poland

[2] Joint Lab Inst Expt Bot & Inst Crop Res, Plant Biotechnol Lab, Prague, Czech Republic

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2011年 / 12卷 / 06期

关键词：

cytokines; pharmaceutical proteins; plant-based production systems; molecular farming; interleukins; transgenic plants; COLONY-STIMULATING FACTOR; HUMAN INTERFERON-BETA; HGM-CSF PRODUCTION; TRANSGENIC TOBACCO; GM-CSF; TRANSIENT EXPRESSION; HUMAN INTERLEUKIN-2; BIOLOGICAL-ACTIVITY; RNA INTERFERENCE; POTATO;

D O I：

10.3390/ijms12063536

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plant-based platforms have been successfully applied for the last two decades for the efficient production of pharmaceutical proteins. The number of commercialized products biomanufactured in plants is, however, rather discouraging. Cytokines are small glycosylated polypeptides used in the treatment of cancer, immune disorders and various other related diseases. Because the clinical use of cytokines is limited by high production costs they are good candidates for plant-made pharmaceuticals. Several research groups explored the possibilities of cost-effective production of animal cytokines in plant systems. This review summarizes recent advances in this field.

引用

页码：3536 / 3552

页数：17

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