Recombinant Cytokines from Plants

被引：27
|
作者：
Sirko, Agnieszka [1 ]
Vanek, Tomas [2 ]
Gora-Sochacka, Anna [1 ]
Redkiewicz, Patrycja [1 ]
机构：
[1] Polish Acad Sci, Inst Biochem & Biophys, PL-02106 Warsaw, Poland
[2] Joint Lab Inst Expt Bot & Inst Crop Res, Plant Biotechnol Lab, Prague, Czech Republic
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2011年 / 12卷 / 06期
关键词：
cytokines; pharmaceutical proteins; plant-based production systems; molecular farming; interleukins; transgenic plants; COLONY-STIMULATING FACTOR; HUMAN INTERFERON-BETA; HGM-CSF PRODUCTION; TRANSGENIC TOBACCO; GM-CSF; TRANSIENT EXPRESSION; HUMAN INTERLEUKIN-2; BIOLOGICAL-ACTIVITY; RNA INTERFERENCE; POTATO;
D O I：
10.3390/ijms12063536
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Plant-based platforms have been successfully applied for the last two decades for the efficient production of pharmaceutical proteins. The number of commercialized products biomanufactured in plants is, however, rather discouraging. Cytokines are small glycosylated polypeptides used in the treatment of cancer, immune disorders and various other related diseases. Because the clinical use of cytokines is limited by high production costs they are good candidates for plant-made pharmaceuticals. Several research groups explored the possibilities of cost-effective production of animal cytokines in plant systems. This review summarizes recent advances in this field.
引用
收藏
页码：3536 / 3552
页数：17
相关论文
共 50 条
  • [31] CYTOKINES YES, CYTOKINES NO, CYTOKINES MAYBE
    DEITCH, EA
    CRITICAL CARE MEDICINE, 1993, 21 (06) : 817 - 819
  • [32] GROWTH-RESPONSES OF COLIFORM BACTERIA TO RECOMBINANT BOVINE CYTOKINES
    HOGAN, JS
    TODHUNTER, DA
    SMITH, KL
    SCHOENBERGER, PS
    SORDILLO, LM
    JOURNAL OF DAIRY SCIENCE, 1993, 76 (04) : 978 - 982
  • [33] Production of an active recombinant thrombomodulin derivative in transgenic tobacco plants and suspension cells
    Helga Schinkel
    Andreas Schiermeyer
    Raphael Soeur
    Rainer Fischer
    Stefan Schillberg
    Transgenic Research, 2005, 14 : 251 - 259
  • [34] PREVENTION AND TREATMENT OF STAPHYLOCOCCUS-AUREUS INFECTIONS WITH RECOMBINANT CYTOKINES
    DALEY, M
    WILLIAMS, T
    COYLE, P
    FURDA, G
    DOUGHERTY, R
    HAYES, P
    CYTOKINE, 1993, 5 (03) : 276 - 284
  • [35] Production of an active recombinant thrombomodulin derivative in transgenic tobacco plants and suspension cells
    Schinkel, H
    Schiermeyer, A
    Soeur, R
    Fischer, R
    Schillberg, S
    TRANSGENIC RESEARCH, 2005, 14 (03) : 251 - 259
  • [36] Plants as Sources of Natural and Recombinant Antimalaria Agents
    Peyman Habibi
    Yao Shi
    Maria Fatima Grossi-de-Sa
    Imran Khan
    Molecular Biotechnology, 2022, 64 : 1177 - 1197
  • [37] Plants as Sources of Natural and Recombinant Antimalaria Agents
    Habibi, Peyman
    Shi, Yao
    Grossi-de-Sa, Maria Fatima
    Khan, Imran
    MOLECULAR BIOTECHNOLOGY, 2022, 64 (11) : 1177 - 1197
  • [38] Pleiotropic effects of recombinant protease inhibitors in plants
    Mangena, Phetole
    FRONTIERS IN PLANT SCIENCE, 2022, 13
  • [39] Assessing Carnivorous Plants for the Production of Recombinant Proteins
    Miguel, Sissi
    Nisse, Estelle
    Biteau, Fiore
    Rottloff, Sandy
    Mignard, Benoit
    Gontier, Eric
    Hehn, Alain
    Bourgaud, Frederic
    FRONTIERS IN PLANT SCIENCE, 2019, 10
  • [40] Optimization of Elastin-Like Polypeptide Fusions for Expression and Purification of Recombinant Proteins in Plants
    Conley, Andrew J.
    Joensuu, Jussi J.
    Jevnikar, Anthony M.
    Menassa, Rima
    Brandle, Jim E.
    BIOTECHNOLOGY AND BIOENGINEERING, 2009, 103 (03) : 562 - 573
12345