Free and hydrogel encapsulated exosome-based therapies in regenerative medicine

被引:135
作者
Akbari, Ali [1 ]
Jabbari, Nassrollah [1 ]
Sharifi, Roholah [2 ]
Ahmadi, Mahdi [3 ]
Vahhabi, Ali [4 ]
Seyedzadeh, Seyyed Javad [5 ,6 ]
Nawaz, Muhammad [7 ]
Szafert, Slawomir [8 ]
Mahmoodi, Monireh [9 ]
Jabbari, Esmaiel [10 ]
Asghari, Rahim [11 ]
Rezaie, Jafar [1 ]
机构
[1] Urmia Univ Med Sci, Solid Tumor Res Ctr, Res Inst Cellular & Mol Med, Orumiyeh, Iran
[2] Harvard Med Sch, Schepens Eye Res Inst, Dept Ophthalmol, Massachusetts Eye & Ear, Boston, MA 02115 USA
[3] Tabriz Univ Med Sci, TB & Lung Dis Res Ctr, Tabriz, Iran
[4] Urmia Univ Med Sci, Fac Med, Dept Immunol & Genet, Orumiyeh, Iran
[5] Urmia Univ Med Sci, Sch Publ Hlth, Dept Med Entomol & Vector Control, Orumiyeh, Iran
[6] Urmia Univ Med Sci, Social Determinants Hlth Res Ctr, Orumiyeh, Iran
[7] Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden
[8] Univ Wroclaw, Fac Chem, F Joliot Curie 14, PL-50383 Wroclaw, Poland
[9] Arak Univ, Fac Sci, Dept Biol, Arak, Iran
[10] Univ South Carolina, Dept Chem Engn, Columbia, SC 29208 USA
[11] Urmia Univ Med Sci, Imam Khomeini Hosp, Dept Oncol, Orumiyeh, Iran
关键词
Mesenchymal stem cell; Exosome; Regenerative medicine; Hydrogels; MESENCHYMAL STEM-CELLS; EXTRACELLULAR VESICLES PROTECT; STROMAL CELLS; FUNCTIONAL RECOVERY; NEUROVASCULAR PLASTICITY; MYOCARDIAL-INFARCTION; MICROVESICLES PROTECT; TRANSFERRIN RECEPTOR; DELIVERY; BRAIN;
D O I
10.1016/j.lfs.2020.117447
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Over the last few decades, mesenchymal stem cells-derived exosomes (MSCs-Ex) have attracted a lot of attention as a therapeutic tool in regenerative medicine. Exosomes are extracellular vehicles (EVs) that play important roles in cell-cell communication through various processes such as stress response, senescence, angiogenesis, and cell differentiation. Success in the field of regenerative medicine sparked exploration of the potential use of exosomes as key therapeutic effectors of MSCs to promote tissue regeneration. Various approaches including direct injection, intravenous injection, intraperitoneal injection, oral administration, and hydrogel-based encapsulation have been exploited to deliver exosomes to target tissues in different disease models. Despite significant advances in exosome therapy, it is unclear which approach is more effective for administering exosomes. Herein, we critically review the emerging progress in the applications of exosomes in the form of free or association with hydrogels as therapeutic agents for applications in regenerative medicine.
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页数:12
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