Vaccination of sheep against M-paratuberculosis:: immune parameters and protective efficacy

被引：45

作者：

Begg, DJ ^{[1
]}

Griffin, JFT ^{[1
]}

机构：

[1] Univ Otago, Dept Microbiol & Immunol, Dis Res Lab, Dunedin, New Zealand

来源：

VACCINE | 2005年 / 23卷 / 42期

关键词：

Johne's disease; protective immunity; vaccination;

D O I：

10.1016/j.vaccine.2005.05.031

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Johne's disease in ruminants is caused by the pathogenic bacterium Mycobacterium avium subspecies paratuberculosis (Map). Currently available Map commercial vaccines protect against clinical disease but not infection. In this study, the proprietary Johne's vaccine Neoparasec (TM) and an aqueous formulation of Map 316F (AquaVax) were tested in sheep. Detailed immunological examination of blood and gut-associated lymphoid tissues was carried out on animals after vaccination and challenge with virulent Map to identify markers of protective immunity. Neoparasec (TM) vaccination provided significant protection against disease whileAquaVax did not. Immune animals had stronger cell-mediated responses and altered proportions of CD4(+), CD8(+), CD25(+) and B cells in blood, spleen and the gut lymphatics, than diseased animals. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：4999 / 5008

页数：10

共 27 条

[1] Adjuvants designed for veterinary and human vaccines [J].

Aucouturier, J ;

Dupuis, L ;

Ganne, V .

VACCINE, 2001, 19 (17-19) :2666-2672

[2] Early immunopathological events in experimental ovine paratuberculosis [J].

Begara-McGorum, I ;

Wildblood, LA ;

Clarke, CJ ;

Connor, KM ;

Stevenson, K ;

McInnes, CJ ;

Sharp, JM ;

Jones, DG .

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 1998, 63 (03) :265-287

[3]

BEGG DJ, IN PRESS INFECT IMMU

[4] Bovine type I and type 2 responses [J].

Brown, WC ;

Rice-Ficht, AC ;

Estes, DM .

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 1998, 63 (1-2) :45-55

[5] Interferon-gamma and interleukin-2 release by lymphocytes derived from the blood, mesenteric lymph nodes and intestines of normal sheep and those affected with paratuberculosis (Johne's disease) [J].

Burrells, C ;

Clarke, CJ ;

Colston, A ;

Kay, JM ;

Porter, J ;

Little, D ;

Sharp, JM .

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 1999, 68 (2-4) :139-148

[6] Immunology: Resistance to paratuberculosis [J].

Chiodini, RJ .

VETERINARY CLINICS OF NORTH AMERICA-FOOD ANIMAL PRACTICE, 1996, 12 (02) :313-&

[7] The pathology and pathogenesis of paratuberculosis in ruminants and other species [J].

Clarke, CJ .

JOURNAL OF COMPARATIVE PATHOLOGY, 1997, 116 (03) :217-261

[8] CONTROL OF JOHNES-DISEASE IN A FLOCK OF SHEEP BY VACCINATION [J].

CRANWELL, MP .

VETERINARY RECORD, 1993, 133 (09) :219-220

[9] Type 1 and type 2 responses in regulation of Ig isotype expression in cattle [J].

Estes, DM ;

Brown, WC .

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2002, 90 (1-2) :1-10

[10]

Griffin J. F. T., 1999, Tubercle and Lung Disease, V79, P135, DOI 10.1054/tuld.1998.0202

← 1 2 3 →