Phenolic constituents of Glycyrrhiza species.: Part 22 -: An isoprenylated flavanone from Glycyrrhiza glabra and REC-assay of licorice phenols

被引：30
|
作者：
Fukai, T [1 ]
Cai, BS [1 ]
Maruno, K [1 ]
Miyakawa, Y [1 ]
Konishi, M [1 ]
Nomura, T [1 ]
机构：
[1] Toho Univ, Fac Pharmaceut Sci, Chiba 2748510, Japan
来源：
PHYTOCHEMISTRY | 1998年 / 49卷 / 07期
关键词：
Glycyrrhiza glabra; Fabaceae; licorice; kanzoh; roots; prenylated pyranoflavanone; kanzonol Z; kanzonol Y; absolute structure; rec-assay; Bacillus subtilis;
D O I：
10.1016/S0031-9422(98)00389-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new prenylated 3-hydroxypyranoflavanone, kanzonol Z, was isolated from cultivated licorice, Glycyrrhiza glabra, and the structure elucidated from spectral evidence. The stereochemical structure of kanzonol Y previously isolated from the licorice has been shown to be (alpha R)-3,5'-diprenyl-alpha,2',4,4'-tetra-hydroxydihydrochalcone by Mosher's method. In a prescreening test for bioactive compounds amongst licorice phenols using a recombinationless mutant of Bacillus subtilis M45, seven compounds showed induction activities of DNA damage. (C) 1998 Elsevier Science Ltd. All rights reserved
引用
收藏
页码：2005 / 2013
页数：9
相关论文
共 7 条
  • [1] Phenolic constituents of Glycyrrhiza species .21. Isoprenylated flavonoids from underground parts of Glycyrrhiza glabra
    Fukai, T
    Sheng, CB
    Horikoshi, T
    Nomura, T
    PHYTOCHEMISTRY, 1996, 43 (05) : 1119 - 1124
  • [2] Phenolic constituents of Glycyrrhiza species. 20. Isoprenoid-substituted flavonoids from Glycyrrhiza glabra
    Fukai, T
    Tantai, L
    Nomura, T
    PHYTOCHEMISTRY, 1996, 43 (02) : 531 - 532
  • [3] PHENOLIC CONSTITUENTS OF GLYCYRRHIZA SPECIES .6. 6 PRENYLATED PHENOLS FROM FROM GLYCYRRHIZA-URALENSIS
    FUKAI, T
    WANG, QH
    NOMURA, T
    PHYTOCHEMISTRY, 1991, 30 (04) : 1245 - 1250
  • [4] PHENOLIC CONSTITUENTS OF GLYCYRRHIZA SPECIES .12. 5 ISOPRENOID-SUBSTITUTED FLAVONOIDS FROM GLYCYRRHIZA-EURYCARPA
    FUKAI, T
    NISHIZAWA, J
    NOMURA, T
    PHYTOCHEMISTRY, 1994, 35 (02) : 515 - 519
  • [5] PHENOLIC CONSTITUENTS OF GLYCYRRHIZA SPECIES .15. 4 ISOPRENOID-SUBSTITUTED FLAVONOIDS FROM GLYCYRRHIZA-ASPERA
    FUKAI, T
    ZENG, L
    NISHIZAWA, J
    WANG, YH
    NOMURA, T
    PHYTOCHEMISTRY, 1994, 36 (01) : 233 - 236
  • [6] PHENOLIC CONSTITUENTS OF GLYCYRRHIZA SPECIES .14. VARIATIONS IN THE CHEMICAL-SHIFT OF THE 5-HYDROXYL PROTON OF ISOFLAVONES - 2 ISOFLAVONES FROM LICORICE
    FUKAI, T
    NISHIZAWA, J
    NOMURA, T
    PHYTOCHEMISTRY, 1994, 36 (01) : 225 - 228
  • [7] CHEMICAL STUDIES OF CHINESE LICORICE-ROOTS .1. ELUCIDATION OF 5 NEW FLAVONOID CONSTITUENTS FROM THE ROOTS OF GLYCYRRHIZA-GLABRA L COLLECTED IN XINJIANG
    KITAGAWA, I
    CHEN, WZ
    HORI, K
    HARADA, E
    YASUDA, N
    YOSHIKAWA, M
    REN, JL
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1994, 42 (05) : 1056 - 1062
1