Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone

被引：137
作者：
Calzolari, Filippo [1 ,2 ]
Michel, Julia [1 ]
Baumgart, Emily Violette [1 ]
Theis, Fabian [3 ,4 ]
Goetz, Magdalena [1 ,2 ,5 ]
Ninkovic, Jovica [1 ,2 ,5 ]
机构：
[1] Helmholtz Ctr, Inst Stem Cell Res, Munich, Germany
[2] Univ Munich, Biomed Ctr, Munich, Germany
[3] Helmholtz Ctr, Inst Computat Biol, Munich, Germany
[4] Tech Univ Munich, Inst Math Sci, Garching, Germany
[5] Univ Munich, Munich Cluster Syst Neurol SYNERGY, Munich, Germany
来源：
NATURE NEUROSCIENCE | 2015年 / 18卷 / 04期
基金：
欧洲研究理事会;
关键词：
LINEAGE PROGRESSION; DIVISION;
D O I：
10.1038/nn.3963
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We analyzed the progeny of individual neural stem cells (NSCs) of the mouse adult subependymal zone (SEZ) in vivo and found a markedly fast lineage amplification, as well as limited NSC self-renewal and exhaustion in a few weeks. We further unraveled the mechanisms of neuronal subtype generation, finding that a higher proportion of NSCs were dedicated to generate deep granule cells in the olfactory bulb and that larger clones were produced by these NSCs.
引用
收藏
页码：490 / +
页数：5
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