Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone

被引：139

作者：

Calzolari, Filippo ^{[1
,2
]}

Michel, Julia ^{[1
]}

Baumgart, Emily Violette ^{[1
]}

Theis, Fabian ^{[3
,4
]}

Goetz, Magdalena ^{[1
,2
,5
]}

Ninkovic, Jovica ^{[1
,2
,5
]}

机构：

[1] Helmholtz Ctr, Inst Stem Cell Res, Munich, Germany

[2] Univ Munich, Biomed Ctr, Munich, Germany

[3] Helmholtz Ctr, Inst Computat Biol, Munich, Germany

[4] Tech Univ Munich, Inst Math Sci, Garching, Germany

[5] Univ Munich, Munich Cluster Syst Neurol SYNERGY, Munich, Germany

来源：

NATURE NEUROSCIENCE | 2015年 / 18卷 / 04期

基金：

欧洲研究理事会;

关键词：

LINEAGE PROGRESSION; DIVISION;

D O I：

10.1038/nn.3963

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We analyzed the progeny of individual neural stem cells (NSCs) of the mouse adult subependymal zone (SEZ) in vivo and found a markedly fast lineage amplification, as well as limited NSC self-renewal and exhaustion in a few weeks. We further unraveled the mechanisms of neuronal subtype generation, finding that a higher proportion of NSCs were dedicated to generate deep granule cells in the olfactory bulb and that larger clones were produced by these NSCs.

引用

页码：490 / +

页数：5

共 19 条

[11] Adult neural stem cells in distinct microdomains generate previously unknown interneuron types [J].

Merkle, Florian T. ;

Fuentealba, Luis C. ;

Sanders, Timothy A. ;

Magno, Lorenza ;

Kessaris, Nicoletta ;

Alvarez-Buylla, Arturo .

NATURE NEUROSCIENCE, 2014, 17 (02) :207-214

[12] Modeling Human Disease with Pluripotent Stem Cells: from Genome Association to Function [J].

Merkle, Florian T. ;

Eggan, Kevin .

CELL STEM CELL, 2013, 12 (06) :656-668

[13] Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain [J].

Mirzadeh, Zaman ;

Merkle, Florian T. ;

Soriano-Navarro, Mario ;

Manuel Garcia-Verdugo, Jose ;

Alvarez-Buylla, Arturo .

CELL STEM CELL, 2008, 3 (03) :265-278

[14] Inducible gene deletion in astroglia and radial glia -: A valuable tool for functional and lineage analysis [J].

Mori, Tetsuji ;

Tanaka, Kohichi ;

Buffo, Annalisa ;

Wurst, Wolfgang ;

Kuehn, Ralf ;

Goetz, Magdalena .

GLIA, 2006, 54 (01) :21-34

[15] Distinct modes of neuron addition in adult mouse neurogenesis [J].

Ninkovic, Jovica ;

Mori, Tetsuji ;

Goetz, Magdalena .

JOURNAL OF NEUROSCIENCE, 2007, 27 (40) :10906-10911

[16] Cell cycle and lineage progression of neural progenitors in the ventricular-subventricular zones of adult mice [J].

Ponti, Giovanna ;

Obernier, Kirsten ;

Guinto, Cristina ;

Jose, Lingu ;

Bonfanti, Luca ;

Alvarez-Buylla, Arturo .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (11) :E1045-E1054

[17] Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging [J].

Ritsma, Laila ;

Ellenbroek, Saskia I. J. ;

Zomer, Anoek ;

Snippert, Hugo J. ;

de Sauvage, Frederic J. ;

Simons, Benjamin D. ;

Clevers, Hans ;

van Rheenen, Jacco .

NATURE, 2014, 507 (7492) :362-+

[18] Spatiotemporal Changes to the Subventricular Zone Stem Cell Pool through Aging [J].

Shook, Brett A. ;

Manz, David H. ;

Peters, John J. ;

Kang, Sangwook ;

Conover, Joanne C. .

JOURNAL OF NEUROSCIENCE, 2012, 32 (20) :6947-6956

[19] Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells [J].

Snippert, Hugo J. ;

van der Flier, Laurens G. ;

Sato, Toshiro ;

van Es, Johan H. ;

van den Born, Maaike ;

Kroon-Veenboer, Carla ;

Barker, Nick ;

Klein, Allon M. ;

van Rheenen, Jacco ;

Simons, Benjamin D. ;

Clevers, Hans .

CELL, 2010, 143 (01) :134-144

← 1 2 →