Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone

被引：139

作者：

Calzolari, Filippo ^{[1
,2
]}

Michel, Julia ^{[1
]}

Baumgart, Emily Violette ^{[1
]}

Theis, Fabian ^{[3
,4
]}

Goetz, Magdalena ^{[1
,2
,5
]}

Ninkovic, Jovica ^{[1
,2
,5
]}

机构：

[1] Helmholtz Ctr, Inst Stem Cell Res, Munich, Germany

[2] Univ Munich, Biomed Ctr, Munich, Germany

[3] Helmholtz Ctr, Inst Computat Biol, Munich, Germany

[4] Tech Univ Munich, Inst Math Sci, Garching, Germany

[5] Univ Munich, Munich Cluster Syst Neurol SYNERGY, Munich, Germany

来源：

NATURE NEUROSCIENCE | 2015年 / 18卷 / 04期

基金：

欧洲研究理事会;

关键词：

LINEAGE PROGRESSION; DIVISION;

D O I：

10.1038/nn.3963

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We analyzed the progeny of individual neural stem cells (NSCs) of the mouse adult subependymal zone (SEZ) in vivo and found a markedly fast lineage amplification, as well as limited NSC self-renewal and exhaustion in a few weeks. We further unraveled the mechanisms of neuronal subtype generation, finding that a higher proportion of NSCs were dedicated to generate deep granule cells in the olfactory bulb and that larger clones were produced by these NSCs.

引用

页码：490 / +

页数：5

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