The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells

被引：14
作者：
Gao, Zhengyin [1 ]
Lei, Weng, I [1 ]
Lee, Leo Tsz On [1 ,2 ,3 ]
机构：
[1] Univ Macau, Fac Hlth Sci, Ctr Canc, Taipa, Macau, Peoples R China
[2] Univ Macau, Fac Hlth Sci, Ctr Reprod Dev & Aging, Taipa, Macau, Peoples R China
[3] Univ Macau, MOE Frontiers Sci Ctr Precis Oncol, Taipa, Macau, Peoples R China
来源：
MOLECULES | 2022年 / 27卷 / 01期
关键词：
G protein-coupled receptor; exchange proteins directly activated by cAMP (EPAC); cAMP; cancer; PROTEIN-KINASE-A; INTESTINAL-PEPTIDE VIP; NUCLEOTIDE-EXCHANGE FACTOR; RECEPTOR EXPRESSION; OXYTOCIN RECEPTORS; INHIBITS MIGRATION; PROSTATE CARCINOMA; COUPLED RECEPTORS; ADENYLYL-CYCLASE; HORMONE AGONISTS;
D O I：
10.3390/molecules27010311
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neuropeptides are autocrine and paracrine signalling factors and mainly bind to G protein-coupled receptors (GPCRs) to trigger intracellular secondary messenger release including adenosine 3 ', 5 '-cyclic monophosphate (cAMP), thus modulating cancer progress in different kind of tumours. As one of the downstream effectors of cAMP, exchange proteins directly activated by cAMP (EPACs) play dual roles in cancer proliferation and metastasis. More evidence about the relationship between neuropeptides and EPAC pathways have been proposed for their potential role in cancer development; hence, this review focuses on the role of neuropeptide/GPCR system modulation of cAMP/EPACs pathways in cancers. The correlated downstream pathways between neuropeptides and EPACs in cancer cell proliferation, migration, and metastasis is discussed to glimmer the direction of future research.
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页数：18
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