Green synthesis of silver nanoparticles using Teucrium polium leaf extract and assessment of their antitumor effects against MNK45 human gastric cancer cell line

被引：113
作者：
Hashemi, Seyedeh Fatemeh [1 ]
Tasharrofi, Nooshin [2 ]
Saber, Mohaddeseh Mahmoudi [1 ,3 ,4 ]
机构：
[1] Shahroud Univ Med Sci, Sch Med, Dept Med Nanotechnol, Shahroud, Iran
[2] Lorestan Univ Med Sci, Fac Pharm, Khorramabad, Iran
[3] Shahroud Univ Med Sci, Sch Med, Dept Tissue Engn, Shahroud, Iran
[4] Shahroud Univ Med Sci, Sch Med, Tissue Engn & Stem Cells Res Ctr, Shahroud, Iran
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2020年 / 1208卷
关键词：
Green synthesis; Silver nanoparticles; Gastric cancer; Teucrium polium; ANTICANCER ACTIVITY; BREAST-CANCER; OXIDE NANOPARTICLES; IN-VITRO; ANTIOXIDANT; GOLD; EFFICACY;
D O I：
10.1016/j.molstruc.2020.127889
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The development of simple, cost effective, biocompatible, eco-friendly and scalable techniques for synthesis of nanomaterials is one of the most important fields of research in nanoscience. Silver nanoparticles (AgNPs) are one of the most frequently used nanomaterials in industrial and biomedical fields due to their chemical stability, good biocompatibility, anti-microbial and anticancer properties, high electrical conductivity, and great optical properties. In the present study, we developed an eco-friendly method to produce stable silver nanoparticles using the leaf extract of a medicinal plant of Teucrium polium (T. polium). The green synthesized silver nanoparticles (T. polium-AgNPs) were characterized by UV-Visible spectroscopy, X-ray diffraction (XRD) study, fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The biosynthesized nanoparticles exhibited significant anticancer activity against MNK45 human gastric cancer cell line. The data obtained in the study shows the potent therapeutic value of T. polium-AgNPs and the scope for further development of anticancer drugs. (C) 2020 Elsevier B.V. All rights reserved.
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页数：6
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