Forkhead box transcription factor, forkhead box A1, shows negative association with lymph node status in endometrial cancer, and represses cell proliferation and migration of endometrial cancer cells

被引：30

作者：

Abe, Yayoi ^{[1
,2
]}

Ijichi, Nobuhiro ^{[1
]}

Ikeda, Kazuhiro ^{[1
]}

Kayano, Hidekazu ^{[3
]}

Horie-Inoue, Kuniko ^{[1
]}

Takeda, Satoru ^{[2
]}

Inoue, Satoshi ^{[1
,4
,5
]}

机构：

[1] Saitama Med Univ, Res Ctr Genom Med, Div Gene Regulat & Signal Transduct, Saitama, Japan

[2] Juntendo Univ, Sch Med, Dept Obstet & Gynecol, Tokyo 113, Japan

[3] Saitama Med Univ, Dept Pathol, Saitama, Japan

[4] Univ Tokyo, Dept Geriatr Med, Tokyo, Japan

[5] Univ Tokyo, Grad Sch Med, Dept Antiaging Med, Tokyo, Japan

来源：

CANCER SCIENCE | 2012年 / 103卷 / 04期

关键词：

BREAST-CANCER; ANDROGEN RECEPTOR; BASEMENT-MEMBRANE; FOXA1; EXPRESSION; LUMINAL SUBTYPE; GENE-EXPRESSION; INHIBITOR; PROGNOSIS; CHROMATIN; THERAPY;

D O I：

10.1111/j.1349-7006.2012.02201.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Endometrial cancer is the most common malignancy of the female genital tract and is associated with poor prognosis. It is primarily a hormone-dependent cancer that is regulated by steroid hormones, including estrogen and progesterone. Forkhead box A1 (FOXA1) is a member of the forkhead box transcription factor family and functions as a pioneer factor in estrogen receptor (ER)-positive breast cancer. In the present study, we investigated the expression of FOXA1 in endometrial cancers by immunohistochemical analysis. Nuclear immunoreactivity for FOXA1 was detected in 40 of 109 cases (37%), and was found to be negatively associated with lymph node status (P = 0.033). In ER-positive Ishikawa endometrial cancer cells, small interfering RNA-mediated downregulation of FOXA1 promoted cell proliferation and migration. Furthermore, exogenously introduced FOXA1 suppressed both proliferation and migration of Ishikawa cells. These results suggest that FOXA1 functions as a tumor suppressor through modulation of proliferation and migration of endometrial cancer cells. (Cancer Sci 2012; 103: 806812)

引用

页码：806 / 812

页数：7

共 36 条

[11] Forkhead-box A1 (FOXA1) expression in breast cancer and its prognostic significance [J].

Habashy, Hany Onsy ;

Powe, Desmond G. ;

Rakha, Emad A. ;

Ball, Graham ;

Paish, Claire ;

Gee, Julia ;

Nicholson, Robert I. ;

Ellis, Ian O. .

EUROPEAN JOURNAL OF CANCER, 2008, 44 (11) :1541-1551

[12] Transducin-like enhancer protein 1 mediates estrogen receptor binding and transcriptional activity in breast cancer cells [J].

Holmes, Kelly A. ;

Hurtado, Antoni ;

Brown, Gordon D. ;

Launchbury, Rosalind ;

Ross-Innes, Caryn S. ;

Hadfield, James ;

Odom, Duncan T. ;

Carroll, Jason S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (08) :2748-2753

[13] FOXA1 is a key determinant of estrogen receptor function and endocrine response [J].

Hurtado, Antoni ;

Holmes, Kelly A. ;

Ross-Innes, Caryn S. ;

Schmidt, Dominic ;

Carroll, Jason S. .

NATURE GENETICS, 2011, 43 (01) :27-U42

[14] Estrogen-related receptor γ modulates cell proliferation and estrogen signaling in breast cancer [J].

Ijichi, Nobuhiro ;

Shigekawa, Takashi ;

Ikeda, Kazuhiro ;

Horie-Inoue, Kuniko ;

Fujimura, Tetsuya ;

Tsuda, Hitoshi ;

Osaki, Akihiko ;

Saeki, Toshiaki ;

Inoue, Satoshi .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2011, 123 (1-2) :1-7

[15] The FoxA factors in organogenesis and differentiation [J].

Kaestner, Klaus H. .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2010, 20 (05) :527-532

[16] Location analysis of estrogen receptor α target promoters reveals that FOXA1 defines a domain of the estrogen response [J].

Laganière, J ;

Deblois, G ;

Lefebvre, C ;

Bataille, AR ;

Robert, F ;

Giguère, V .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (33) :11651-11656

[17]

Lax S F, 1997, Verh Dtsch Ges Pathol, V81, P228

[18] Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification [J].

Lax, SF .

VIRCHOWS ARCHIV, 2004, 444 (03) :213-223

[19]

Lin L, 2002, CANCER RES, V62, P5273

[20] Regulatory mechanisms controlling human E-cadherin gene expression [J].

Liu, YN ;

Lee, WW ;

Wang, CY ;

Chao, TH ;

Chen, Y ;

Chen, JH .

ONCOGENE, 2005, 24 (56) :8277-8290

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