Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis

被引：165

作者：

Maher, Jacquelyn J. ^{[1
,4
]}

Leon, Pablo ^{[2
,3
]}

Ryan, James C. ^{[1
,3
]}

机构：

[1] Univ Calif San Francisco, Dept Med, San Francisco, CA USA

[2] Univ Calif San Francisco, Dept Surg, San Francisco, CA 94143 USA

[3] Vet Affairs Med Ctr, San Francisco, CA 94121 USA

[4] Univ Calif San Francisco, Ctr Liver, San Francisco, CA 94143 USA

来源：

HEPATOLOGY | 2008年 / 48卷 / 02期

关键词：

D O I：

10.1002/hep.22399

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Obesity is an inflammatory disorder characterized by heightened activity of the innate immune system. Innate immune activation is central to the development of obesity-related insulin resistance; it also plays an important role in obesity-related tissue damage, such as that seen in atherosclerosis. Recent research has implicated the innate immune system in the pathophysiology of obesity-related liver disease. This review summarizes how innate immune processes, occurring both within and outside the liver, cause not only insulin resistance but also end-organ damage in the form of nonalcoholic fatty liver disease.

引用

页码：670 / 678

页数：9

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