Synthesis of a new chiral peptide analogue of DNA using ornithine subunits and solid-phase peptide synthesis methodologies

被引：0

作者：

Lioy, E ^{[1
]}

Kessler, H ^{[1
]}

机构：

[1] TECH UNIV MUNICH,INST ORGAN CHEM & BIOCHEM,D-85747 GARCHING,GERMANY

来源：

LIEBIGS ANNALEN | 1996年 / 02期

关键词：

peptide nucleic acid; solid-phase peptide synthesis; Fmoc strategy;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this paper we describe the synthesis of chiral peptide nucleic acids (PNAs) 1-3 using SPPS methodologies. Starting material for the monomer units was the commercially available amino acid ornithine. L- or D-ornithine and the nucleo-base thymine were linked by a carboxymethylene spacer giving the chiral monomers L-7 and D-7. The SPPS was performed according to the Fmoc strategy.

引用

页码：201 / 204

页数：4

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