Does 6% hydroxyethyl starch 130/0.4 impact differently on blood glucose than 4% gelatin in patients receiving open heart surgery?

被引：9
作者：
Lou, S. [1 ]
Bian, L. [1 ]
Long, C. [1 ]
Wang, Z. [1 ]
Ma, J. [1 ]
Zhou, B. [1 ]
机构：
[1] CAMS, Dept Cardiopulm Bypass, Cardiovasc Inst, FuWai Hosp, Beijing 100037, Peoples R China
来源：
PERFUSION-UK | 2012年 / 27卷 / 02期
关键词：
artificial colloid; glucose; cardiopulmonary bypass; adult; cardiac surgery; CRITICALLY-ILL PATIENTS; INFLAMMATORY RESPONSE; CARDIAC-SURGERY; NONDIABETIC PATIENTS; ELEVATION; ALBUMIN; THERAPY; MODEL;
D O I：
10.1177/0267659111426920
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objectives: To investigate whether starch-based colloid may impact differently on blood glucose than a gelatin-based colloid in adult patients receiving open heart surgery. Methods: 70 adult patients scheduled for elective first-time cardiac surgery were enrolled and randomized into two groups. The circuits were primed with either 6% HES 130/0.4 or 4% gelatin. The peak glucose level, incidence of hyperglycemia, glucose variation and glucose level at different time points during operation were compared between the two groups. A p-value <= 0.05 was accepted as significant. Results: The peak glucose (150 +/- 30mg/dl vs 142 +/- 27, p=0.236) and glucose variation demonstrated by standard deviation (26 +/- 12mg/dl vs 23 +/- 11mg/dl, p=0.202) were comparable between the two groups. Repeated measurement ANOVA revealed that the main effect for artificial colloid was not significant (p=0.349). Conclusions: With the data available, we could not prove that starch-based colloid (HES130) had a different impact on intra-operative blood glucose than a gelatin-based colloid in adult patients receiving open heart surgery.
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收藏
页码：113 / 118
页数：6
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