An Insight into the Sex Differences in COVID-19 Patients: What are the Possible Causes?

被引：82

作者：

Maleki Dana, Parisa ^{[1
]}

Sadoughi, Fatemeh ^{[1
]}

Hallajzadeh, Jamal ^{[2
]}

Asemi, Zatollah ^{[1
]}

Mansournia, Mohammad Ali ^{[3
]}

Yousefi, Bahman ^{[4
,5
]}

Momen-Heravi, Mansooreh ^{[6
,7
]}

机构：

[1] Kashan Univ Med Sci, Inst Basic Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran

[2] Maragheh Univ Med Sci, Res Ctr Evidence Based Hlth Management, Dept Biochem & Nutr, Maragheh, Iran

[3] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Tehran, Iran

[4] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran

[5] Tabriz Univ Med Sci, Fac Med, Dept Biochem, Tabriz, Iran

[6] Kashan Univ Med Sci, Sch Med, Dept Infect Dis, Kashan, Iran

[7] Kashan Univ Med Sci, Infect Dis Res Ctr, Kashan, Iran

来源：

PREHOSPITAL AND DISASTER MEDICINE | 2020年 / 35卷 / 04期

关键词：

ACE2; COVID-19; estrogen; gender; sex differences; sex hormones; testosterone; RESPIRATORY SYNDROME CORONAVIRUS; SPIKE PROTEIN; ACE2; RECEPTOR; TMPRSS2; MODULATION;

D O I：

10.1017/S1049023X20000837

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Studies have reported a sex bias in case fatalities of COVID-19 patients. Moreover, it is observed that men have a higher risk of developing a severe form of the disease compared to women, highlighting the importance of disaggregated data of male and female COVID-19 patients. On the other hand, other factors (eg, hormonal levels and immune functions) also need to be addressed due to the effects of sex differences on the outcomes of COVID-19 patients. An insight into the underlying causes of sex differences in COVID-19 patients may provide an opportunity for better care of the patients or prevention of the disease. The current study reviews the reports concerning with the sex differences in COVID-19 patients. It is explained how sex can affect angiotensin converting enzyme-2 (ACE2), that is a key component for the pathogenesis of COVID-19, and summarized the gender differences in immune responses and how sex hormones are involved in immune processes. Furthermore, the available data about the impact of sex hormones on the immune functions of COVID-19 cases are looked into.

引用

页码：438 / 441

页数：4

共 41 条

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