In Human-Machine Interface (HMI) design, several parameters have to be correctly evaluated in order to guarantee a good level of safety and well-being of users (humans) and to avoid health problems like muscular-skeletal disease. ISO Standards give us a good reference on Ergonomics and Comfort: ISO 11228 regulation; it deals with qualitative/quantitative parameters for evaluating Postural Ergonomics, using a "Postural Load Index", in push/pull, in manual loads' lifting and carrying and in repetitive actions; those parameters can represent the Ergonomics level of examined posture. While bibliographic references suggest different methods to make ergonomic evaluation like RULA, LUBA and REBA, the state of the art about comfort/discomfort evaluation shows the need of an objective method to evaluate "effect in the internal body" and "perceived effects" in several schemes of comfort perception like Moes', Vink & Hallback's and Naddeo & Cappetti's ones; postural comfort is one of the aspect of comfort/discomfort perception and this paper proposes a new quantitative method for evaluating this aspect of comfort, based on anthropometric parameters and upper limbs posture. The target of this paper is to present and test a "general purpose" method of comfort-measurement that can be applied to different industrial cases: in workspace environments, in automotive passenger compartments, in aeronautic cockpit or in industrial assembly lines. Relevance to industry: The method presented in this paper may allow industrial designers to provide an assessment of products' perceived comfort in the early stage of the product development process by making a posture-based quantitative evaluation; it also allows designers to make a comfort driven redesign of existing products' configuration for improving and innovating them. (C) 2015 Elsevier ay. All rights reserved.