Enhancing memory performance with rTMS in healthy subjects and individuals with Mild Cognitive Impairment: the role of the right dorsolateral prefrontal cortex

被引：111
作者：
Turriziani, Patrizia [1 ]
Smirni, Daniela [1 ]
Zappala, Giuseppe [4 ]
Mangano, Giuseppa R. [1 ]
Oliveri, Massimiliano [1 ,3 ]
Cipolotti, Lisa [1 ,2 ]
机构：
[1] Univ Palermo, Dipartimento Psicol, I-90128 Palermo, Italy
[2] Natl Hosp Neurol & Neurosurg, Dept Neuropsychol, London, England
[3] IRCCS Fdn Santa Lucia, Rome, Italy
[4] ARNAS Garibaldi, Unit Neurol Cognitiva & Riabilitaz, Catania, Italy
来源：
FRONTIERS IN HUMAN NEUROSCIENCE | 2012年 / 6卷
关键词：
rTMS; DLPFC; MCI; recognition memory; retrieval; LONG-TERM-MEMORY; TRANSCRANIAL MAGNETIC STIMULATION; EPISODIC MEMORY; RECOGNITION MEMORY; ALZHEIMERS-DISEASE; LOBE CONTRIBUTIONS; BRAIN-STIMULATION; FRONTAL-CORTEX; MOTOR CORTEX; OLDER ADULTS;
D O I：
10.3389/fnhum.2012.00062
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A debated question in the literature is the degree of anatomical and functional lateralization of the executive control processes sub-served by the dorsolateral prefrontal cortex (DLPFC) during recognition memory retrieval. We investigated if transient inhibition and excitation of the left and right DLPFC atretrieval by means of repetitive transcranial magnetic stimulation (rTMS) modulate recognition memory performance in 100 healthy controls (HCs) and in eight patients with Mild Cognitive Impairment (MCI). Recognition memory tasks of faces, buildings, and words were used in different experiments. rTMS-inhibition of the right DLPFC enhanced recognition memory in both HCs and MCIs. rTMS-excitation of the same region in HCs deteriorated memory performance. Inhibition of the right DLPFC could modulate the excitability of a network of brain regions, in the ipsilateral as well as in the contralateral hemisphere, enhancing function in HCs or restoring an adaptive equilibrium in MCI.
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页数：8
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