Identification of New CRF51_01B in Singapore Using Full Genome Analysis of Three HIV Type 1 Isolates

被引：0
作者：
Ng, Oon Tek [1 ,2 ]
Eyzaguirre, Lindsay M. [3 ]
Carr, Jean K.
Chew, Kuan Kiat [2 ]
Lin, Li [2 ]
Chua, Arlene [2 ]
Leo, Yee Sin [2 ]
Redd, Andrew D. [4 ]
Quinn, Thomas C. [1 ,4 ]
Laeyendecker, Oliver [1 ,4 ]
机构：
[1] Johns Hopkins Med Inst, Johns Hopkins Sch Med, Baltimore, MD 21205 USA
[2] Tan Tock Seng Hosp, Dept Infect Dis, Singapore, Singapore
[3] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA
[4] NIAID, Immunoregulat Lab, Div Intramural Res, NIH, Baltimore, MD USA
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2012年 / 28卷 / 05期
关键词：
CIRCULATING RECOMBINANT FORM; THAILAND; CRF15-01B; CRF33-01B; SEQUENCE; MALAYSIA;
D O I：
10.1089/aid.2011.0177
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A recent HIV-1 molecular epidemiology survey in Singapore identified a novel CRF01_AE/B recombinant form, which accounted for 13 (11.9%) of 109 patient samples. Peripheral blood mononuclear cell DNA from three of these 13 patients was used to generate near full-length sequences to characterize the novel CRF01_AE/B recombinant form. The three isolates had a recombinant structure composed of CRF01_AE and subtype B, and shared identical breakpoints. As the three patients were not epidemiologically linked, this recombinant form has been designated CRF51_01B. Identification of the novel recombinant forms indicates ongoing active HIV-1 transmission in Singapore.
引用
收藏
页码：527 / 530
页数：4
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