A Novel Asymmetric Synthesis of (+)-Deoxytylophorinine

被引：2
|
作者：
Lv, Haining [1 ,2 ]
Xu, Song [1 ,2 ]
Ma, Shuanggang [1 ,2 ]
Liu, Yunbao [1 ,2 ]
Li, Yong [1 ,2 ]
Qu, Jing [1 ,2 ]
Yu, Shishan [1 ,2 ]
机构：
[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
[2] Peking Union Med Coll, Beijing 100050, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2015年 / 47卷 / 10期
关键词：
phenanthroindolizidine alkaloids; (+)-deoxytylophorinine; asymmetric synthesis; anticancer agents; non-proteinogenic -amino acids; PHENANTHROINDOLIZIDINE ALKALOIDS; AMINO-ACIDS; PHENANTHROQUINOLIZIDINES; CRYPTOPLEURINE; COMPLEXES; NI(II);
D O I：
10.1055/s-0034-1380137
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel asymmetric synthesis of a phenanthroindolizidine alkaloid, (+)-deoxytylophorinine, is reported, which uses a chiral nickel(II) complex of a glycine Schiff base to synthesize a substituted (R)-3-phenanthrylalanine as a key intermediate and Meldrum's acid to construct the E ring.
引用
收藏
页码：1399 / 1404
页数：6
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