A Novel Asymmetric Synthesis of (+)-Deoxytylophorinine

被引：2

作者：

Lv, Haining ^{[1
,2
]}

Xu, Song ^{[1
,2
]}

Ma, Shuanggang ^{[1
,2
]}

Liu, Yunbao ^{[1
,2
]}

Li, Yong ^{[1
,2
]}

Qu, Jing ^{[1
,2
]}

Yu, Shishan ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2015年 / 47卷 / 10期

关键词：

phenanthroindolizidine alkaloids; (+)-deoxytylophorinine; asymmetric synthesis; anticancer agents; non-proteinogenic -amino acids; PHENANTHROINDOLIZIDINE ALKALOIDS; AMINO-ACIDS; PHENANTHROQUINOLIZIDINES; CRYPTOPLEURINE; COMPLEXES; NI(II);

D O I：

10.1055/s-0034-1380137

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel asymmetric synthesis of a phenanthroindolizidine alkaloid, (+)-deoxytylophorinine, is reported, which uses a chiral nickel(II) complex of a glycine Schiff base to synthesize a substituted (R)-3-phenanthrylalanine as a key intermediate and Meldrum's acid to construct the E ring.

引用

页码：1399 / 1404

页数：6

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