B cells in clinical transplantation tolerance

被引：8
作者：
Adams, Andrew B.
Newell, Kenneth A. [1 ]
机构：
[1] Emory Univ, Dept Surg, Atlanta, GA 30322 USA
来源：
SEMINARS IN IMMUNOLOGY | 2012年 / 24卷 / 02期
关键词：
B cell; Transplantation; Tolerance; Immune regulation; REGULATORY T-CELLS; LONG-TERM; ALLOGRAFT TOLERANCE; UNITED-STATES; REJECTION; IDENTIFICATION; MAINTENANCE; ALEMTUZUMAB; RECIPIENTS; SIGNATURE;
D O I：
10.1016/j.smim.2011.08.019
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The rarity of tolerance following clinical transplantation has complicated the study of the responsible mechanisms. Several recent studies of kidney transplant recipients have demonstrated an association between increased numbers of B cells with less mature, inhibitory phenotypes and a state of tolerance. While a growing body of evidence from experimental models supports a role for B cells in regulating or suppressing immune responses, a causative role for B cells in clinical transplantation tolerance has yet to be proven. If B cells are conclusively shown to participate in the development of transplantation tolerance, it will be important to define the responsible mechanisms in order to design monitoring assays and immunosuppressive regimens that favor the development of tolerance. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：92 / 95
页数：4
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