Targeting the cancer lesion, not the whole prostate

被引:9
作者
Bedi, Nishant [1 ,2 ]
Reddy, Deepika [1 ,2 ]
Ahmed, Hashim U. [1 ,2 ]
机构
[1] Imperial Coll Healthcare NHS Trust, Charing Cross Hosp, Imperial Urol, London, England
[2] Imperial Coll London, Dept Surg & Canc, Div Surg, Imperial Prostate, London, England
基金
英国惠康基金;
关键词
Prostate cancer; focal therapy; high-intensity focused ultrasound (HIFU); cryotherapy; index lesion; irreversible electroporation (IRE); vascular-targeted photodynamic therapy (VTP); focal brachytherapy; laser interstitial therapy (LITT); focal radiofrequency ablation (focal RFA); photodynamic therapy (PDT); INTENSITY FOCUSED ULTRASOUND; PROSPECTIVE MULTICENTRIC HEMIABLATION; FOCAL THERAPY; IRREVERSIBLE ELECTROPORATION; RADICAL PROSTATECTOMY; FUNCTIONAL OUTCOMES; INDEX LESION; FOLLOW-UP; BRACHYTHERAPY; CRYOTHERAPY;
D O I
10.21037/tau.2019.09.12
中图分类号
R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
摘要
Modern cancer treatment aims to conserve as much healthy tissue as possible. This has been challenging in the treatment of prostate cancer due to the difficulty in imaging the gland and concerns over leaving multifocal cancer untreated. With improvements in imaging and understanding of multifocal prostate cancer evidence now shows accurate treatment of just the primary focus of cancer or the index lesion can control progression or recurrence of the disease. Many different energy sources are now available to target the cancer lesion within the prostate with less significant side-effects on urinary and sexual function compared to radical treatment. Evidence shows that men value these functions highly and would even trade years of life in exchange for preserved retention of continence or erectile function. Focal treatment of prostate cancer aims to provide both cancer control and preservation of sexual and urinary functions so that men do not have to make a choice between the two. This is a treatment option that men clearly want and deserve.
引用
收藏
页码:1518 / 1525
页数:8
相关论文
共 56 条
  • [51] Identifying the Index Lesion with Template Prostate Mapping Biopsies
    Valerio, Massimo
    Anele, Chukwuemeka
    Freeman, Alex
    Jameson, Charles
    Singh, Paras B.
    Hu, Yipeng
    Emberton, Mark
    Ahmed, Hashim U.
    [J]. JOURNAL OF UROLOGY, 2015, 193 (04) : 1185 - 1190
  • [52] The Role of Focal Therapy in the Management of Localised Prostate Cancer: A Systematic Review
    Valerio, Massimo
    Ahmed, Hashim U.
    Emberton, Mark
    Lawrentschuk, Nathan
    Lazzeri, Massimo
    Montironi, Rodolfo
    Nguyen, Paul L.
    Trachtenberg, John
    Polascik, Thomas J.
    [J]. EUROPEAN UROLOGY, 2014, 66 (04) : 732 - 751
  • [53] The correlation between the electrode configuration and histopathology of irreversible electroporation ablations in prostate cancer patients
    van den Bos, W.
    de Bruin, D. M.
    Jurhill, R. R.
    Savci-Heijink, C. D.
    Muller, B. G.
    Varkarakis, I. M.
    Skolarikos, A.
    Zondervan, P. J.
    Laguna-Pes, M. P.
    Wijkstra, H.
    de Reijke, T. M.
    de la Rosette, J. J. M. C. H.
    [J]. WORLD JOURNAL OF UROLOGY, 2016, 34 (05) : 657 - 664
  • [54] Follow-up of Prostatectomy versus Observation for Early Prostate Cancer
    Wilt, Timothy J.
    Jones, Karen M.
    Barry, Michael J.
    Andriole, Gerald L.
    Culkin, Daniel
    Wheeler, Thomas
    Aronson, William J.
    Brawer, Michael K.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (02) : 132 - 142
  • [55] Wilt Timothy J., 2012, Journal of the National Cancer Institute Monographs, P184, DOI 10.1093/jncimonographs/lgs041
  • [56] Zlotta AR, 1998, BRIT J UROL, V81, P265