Local drug delivery from hydroxyapatite ceramic fibres

被引：0

作者：

Ravelingien, M. ^{[1
,2
]}

Smets, N. ^{[2
]}

Mullens, S. ^{[1
]}

Luyten, J. ^{[1
]}

Vervaet, C. ^{[2
]}

Remon, J. P. ^{[2
]}

机构：

[1] VITO, Boeretang 200, B-2400 Mol, Belgium

[2] Univ Ghent, Lab Pharmaceut Technol, Ghent, Belgium

来源：

4TH EUROPEAN CONFERENCE OF THE INTERNATIONAL FEDERATION FOR MEDICAL AND BIOLOGICAL ENGINEERING | 2009年 / 22卷 / 1-3期

关键词：

hydroxyapatite; drug delivery; bone infections; ANTIBIOTIC DELIVERY; CALCIUM-PHOSPHATE; GENTAMICIN; RELEASE; OSTEOMYELITIS; IMPLANT; PROPHYLAXIS; VANCOMYCIN; COATINGS; CARRIER;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Hydroxyapatite (HA) ceramic fibres were fabricated by diffusion-induced phase separation. The fibres were loaded with riboflavin phosphate (RP) as a model drug of water soluble antibiotics to treat orthopedic infections and subsequently spray-coated with polylactide (PLA) or poly(lactide-co-glycolide) (PLGA). An in vitro dissolution test showed a burst release within the first day from fibres with a 3 mu m PLA or PLGA coating. This initial burst release was already reduced by a 7 mu m PLA or PLGA coating. The dissolution profile of fibres with a 14 mu m PLA or PLGA coating showed a RP release of 80% after 28 days. The 14 mu m PLA coating exhibited a lag phase of two days, followed by a near zero order release until the 21st day.

引用

页码：2269 / 2272

页数：4

共 20 条

[1] In vitro-in vivo characterization of gentamicin bone implants [J].

Baro, M ;

Sánchez, E ;

Delgado, A ;

Perera, A ;

Évora, C .

JOURNAL OF CONTROLLED RELEASE, 2002, 83 (03) :353-364

[2] The significance of infection related to orthopedic devices and issues of antibiotic resistance [J].

Campoccia, D ;

Montanaro, L ;

Arciola, CR .

BIOMATERIALS, 2006, 27 (11) :2331-2339

[3] Association of vancomycin and calcium phosphate by dynamic compaction: in vitro characterization and microbiological activity [J].

Gautier, H ;

Daculsi, G ;

Merle, C .

BIOMATERIALS, 2001, 22 (18) :2481-2487

[4] High release of antibiotic from a novel hydroxyapatite with bimodal pore size distribution [J].

Hasegawa, M ;

Sudo, A ;

Komlev, VS ;

Barinov, SM ;

Uchida, A .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2004, 70B (02) :332-339

[5] Synthesis of antibiotic-loaded interporous hydroxyapatite blocks by vacuum method and in vitro drug release testing [J].

Itokazu, M ;

Yang, WY ;

Aoki, T ;

Ohara, A ;

Kato, N .

BIOMATERIALS, 1998, 19 (7-9) :817-819

[6] Carrier systems for the local delivery of antibiotics in bone infections [J].

Kanellakopoulou, K ;

Giamarellos-Bourboulis, EJ .

DRUGS, 2000, 59 (06) :1223-1232

[7]

Lambotte J C, 1998, Chirurgie, V123, P572, DOI 10.1016/S0001-4001(99)80006-3

[8]

LeGeros RZ, 2002, CLIN ORTHOP RELAT R, P81

[9] Osteomyelitis [J].

Lew, DP ;

Waldvogel, FA .

LANCET, 2004, 364 (9431) :369-379

[10]

Li LC, 2002, ADV DRUG DELIVER REV, V54, P963

← 1 2 →