Water-Soluble, Donor-Acceptor Biphenyl Derivatives in the 2-(o-Nitrophenyl)propyl Series: Highly Efficient Two-Photon Uncaging of the Neurotransmitter ?-Aminobutyric Acid at ?=800 nm

被引：103

作者：

Donato, Loic ^{[1
]}

Mourot, Alexandre ^{[2
]}

Davenport, Christopher M. ^{[2
]}

Herbivo, Cyril ^{[1
]}

Warther, David ^{[1
]}

Leonard, Jeremie ^{[3
]}

Bolze, Frederic ^{[4
]}

Nicoud, Jean-Francois ^{[4
]}

Kramer, Richard H. ^{[2
]}

Goeldner, Maurice ^{[1
]}

Specht, Alexandre ^{[1
]}

机构：

[1] CNRS, UDS, Lab Concept & Applicat Mol Bioactives, Fac Pharm,UMR 7199, F-67400 Illkirch Graffenstaden, France

[2] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[3] Univ Strasbourg, CNRS, Inst Phys & Chim Mat Strasbourg, UMR 7504, Strasbourg, France

[4] CNRS, UDS, Lab Biophoton & Pharmacol, Fac Pharm,UMR 7213, F-67400 Illkirch Graffenstaden, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 08期

关键词：

biaryls; caged compounds; neurotransmitters; photolysis; synthetic methods; PHOTOREMOVABLE PROTECTING GROUPS; DENDRITIC SPINES; GLUTAMATE; ABSORPTION; MICROSCOPY;

D O I：

10.1002/anie.201106559

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Rattling the cage: The two γ-aminobutyric acid (GABA) derivatives 1 and 2 exhibit efficient and rapid (<5à- 10 -6 s) GABA photorelease upon one-photon excitation combined with two-photon uncaging cross-section at λ=800 nm. Compounds 1 and 2 were successfully used for two-photon GABA release in intact brain tissue, thus offering attractive perspectives in chemical neurosciences. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1840 / 1843

页数：4

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