Osteoarthritis year 2011 in review: biology

被引：33

作者：

Lotz, M. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

来源：

OSTEOARTHRITIS AND CARTILAGE | 2012年 / 20卷 / 03期

关键词：

Angiogenesis; Autophagy; Lubricin; Mitochondria; GENETICALLY HETEROGENEOUS MICE; EXTENDS LIFE-SPAN; CARTILAGE DEGENERATION; OSTEOCHONDRAL JUNCTION; RHEUMATOID-ARTHRITIS; GROWTH-FACTOR; CELL-DEATH; STEM-CELLS; RAT MODEL; LUBRICIN;

D O I：

10.1016/j.joca.2011.11.015

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

This review is focused on advances in understanding the biology of joint homeostasis and osteoarthritis (OA) pathogenesis mechanisms that have led to proof of concept studies on new therapeutic approaches. The three selected topics include angiogenesis in joint tissues, biomechanics and joint lubrication and mitochondrial dysfunction. This new information represents progress in the integration of mechanisms that control multiple aspects of OA pathophysiology. (C) 2011 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

引用

页码：192 / 196

页数：5

共 52 条

[1]

Ashraf S, 2011, ARTHRITIS RHEUM

[2] Increased vascular penetration and nerve growth in the meniscus: a potential source of pain in osteoarthritis [J].

Ashraf, Sadaf ;

Wibberley, Helen ;

Mapp, Paul Ian ;

Hill, Roger ;

Wilson, Deborah ;

Walsh, David Andrew .

ANNALS OF THE RHEUMATIC DISEASES, 2011, 70 (03) :523-529

[3] Hyaluronan synthesis and degradation in cartilage and bone [J].

Bastow, E. R. ;

Byers, S. ;

Golub, S. B. ;

Clarkin, C. E. ;

Pitsillides, A. A. ;

Fosang, A. J. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2008, 65 (03) :395-413

[4]

Campisi J., 2011, SEMIN CANC BIOL

[5]

Carames B, 2011, ARTHRITIS RHEUM

[6]

Carames B., 2011, ANN RHEUM DIS

[7] Autophagy Is a Protective Mechanism in Normal Cartilage, and Its Aging-Related Loss Is Linked With Cell Death and Osteoarthritis [J].

Carames, Beatriz ;

Taniguchi, Noboru ;

Otsuki, Shuhei ;

Blanco, Francisco J. ;

Lotz, Martin .

ARTHRITIS AND RHEUMATISM, 2010, 62 (03) :791-801

[8] Molecular mechanisms and clinical applications of angiogenesis [J].

Carmeliet, Peter ;

Jain, Rakesh K. .

NATURE, 2011, 473 (7347) :298-307

[9] The Impact of Anterior Cruciate Ligament Injury on Lubricin Metabolism and the Effect of Inhibiting Tumor Necrosis Factor α on Chondroprotection in an Animal Model [J].

Elsaid, K. A. ;

Machan, J. T. ;

Waller, K. ;

Fleming, B. C. ;

Jay, G. D. .

ARTHRITIS AND RHEUMATISM, 2009, 60 (10) :2997-3006

[10] Endostatin promotes the anabolic program of rabbit chondrocyte [J].

Feng, Y ;

Wu, YP ;

Zhu, XD ;

Zhang, YH ;

Ma, QJ .

CELL RESEARCH, 2005, 15 (03) :201-206

← 1 2 3 4 5 6 →