Influence of mineralized collagen fibrils on the thermo-sensitivity of an injectable scaffold for bone regeneration

被引：2

作者：

Huang, Zhi ^{[1
]}

Li, Xiaoming ^{[2
]}

Feng, Qingling ^{[1
]}

Rong, Ziqin ^{[1
]}

Yu, Bo ^{[3
]}

机构：

[1] Tsinghua Univ, Dept Mat Sci & Engn, Key Lab Adv Mat, Beijing 100084, Peoples R China

[2] Beihang Univ, Sch Biol Sci & Med Engn, Beijing, Peoples R China

[3] So Med Univ, Zhujiang Hosp, Dept Orthoped, Guangzhou, Guangdong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MATERIALS RESEARCH | 2011年 / 102卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Mineralized collagen; Chitosan; Bone; Thermo-sensitive; Injectable; CHITOSAN; GELATION; HYDROXYAPATITE;

D O I：

10.3139/146.110594

中图分类号：

TF [冶金工业];

学科分类号：

0806 ;

摘要：

Mineralized collagen fibrils are the basis for various connective tissues such as bone and cartilage. Injectable biomaterials incorporating mineralized collagen fibrils are applicable to a wide variety of implant types for bone regeneration. A mineralized collagen fibrils/chitosan thermo-sensitive and injectable scaffold for bone regeneration was prepared successfully. The thermo-sensitive properties of the mineralized collagen fibrils/chitosan system depended on the concentrations of mineralized collagen fibrils. 0.02 g mL(-1) of mineralized collagen fibrils filler was appropriate for application since it allowed lower gelation temperature and more rapid gelation following injection, due to the increased hydrogen bonds between the collagen in mineralized collagen fibrils and chitosan.

引用

页码：1384 / 1390

页数：7

共 28 条

[1] Hydroxyapatite surface solubility and effect on cell adhesion [J].

Bertazzo, Sergio ;

Zambuzzi, Willian F. ;

Campos, Daniela D. P. ;

Ogeda, Thais L. ;

Ferreira, Carmen V. ;

Bertran, Celso A. .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2010, 78 (02) :177-184

[2] Thermoreversible gelation of hydroxypropylcellulose aqueous solutions [J].

Carotenuto, Claudia ;

Grizzuti, Nino .

RHEOLOGICA ACTA, 2006, 45 (04) :468-473

[3] Intermolecular interactions in electrospun collagen-chitosan complex nanofibers [J].

Chen, Zonggang ;

Mo, Xiumei ;

He, Chuanglong ;

Wang, Hongsheng .

CARBOHYDRATE POLYMERS, 2008, 72 (03) :410-418

[4] Monolithic gelation of chitosan solutions via enzymatic hydrolysis of urea [J].

Chenite, A. ;

Gori, S. ;

Shive, M. ;

Desrosiers, E. ;

Buschmann, M. D. .

CARBOHYDRATE POLYMERS, 2006, 64 (03) :419-424

[5] Novel injectable neutral solutions of chitosan form biodegradable gels in situ [J].

Chenite, A ;

Chaput, C ;

Wang, D ;

Combes, C ;

Buschmann, MD ;

Hoemann, CD ;

Leroux, JC ;

Atkinson, BL ;

Binette, F ;

Selmani, A .

BIOMATERIALS, 2000, 21 (21) :2155-2161

[6] Effect of urea on solution behavior and heat-induced gelation of chitosan-β-glycerophosphate [J].

Cho, J ;

Heuzey, MC ;

Bégin, A ;

Carreau, PJ .

CARBOHYDRATE POLYMERS, 2006, 63 (04) :507-518

[7] Gel point investigation of a chitosan system using Fourier transform rheometry and multi-frequency excitation [J].

Cho, Jaepyoung ;

Heuzey, Marie-Claude ;

Hamdine, Melina .

MACROMOLECULAR MATERIALS AND ENGINEERING, 2007, 292 (05) :571-581

[8] Physical gelation of chitosan in the presence of β-glycerophosphate:: The effect of temperature [J].

Cho, JY ;

Heuzey, MC ;

Bégin, A ;

Carreau, PJ .

BIOMACROMOLECULES, 2005, 6 (06) :3267-3275

[9] Inflammatory response on injection of chitosan/GP to the brain [J].

Crompton, K. E. ;

Tomas, D. ;

Finkelstein, D. I. ;

Marr, M. ;

Forsythe, J. S. ;

Horne, M. K. .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2006, 17 (07) :633-639

[10] Self-assembly of mineralized collagen composites [J].

Cui, Fu-Zhai ;

Li, Yan ;

Ge, Jun .

MATERIALS SCIENCE & ENGINEERING R-REPORTS, 2007, 57 (1-6) :1-27

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