Enantioselective one-pot synthesis of 2-amino-4H-chromenes via C-H oxidation and Michael addition/ring closure sequences

被引：5

作者：

Kim, Kyeong Seop ^{[1
,2
]}

Kim, Dae Young ^{[1
,2
]}

机构：

[1] Soonchunhyang Univ, Dept Chem, Asan 31538, Chungnam, South Korea

[2] Soonchunhyang Univ, ICT Environm Hlth Syst, Asan 31538, Chungnam, South Korea

来源：

SYNTHETIC COMMUNICATIONS | 2022年 / 52卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

2-Amino-4H-chromene; asymmetric catalysis; organocatalysis; o-quinone methides; ORTHO-QUINONE METHIDES; ASYMMETRIC CONJUGATE ADDITION; FRIEDEL-CRAFTS ALKYLATION; DIELS-ALDER REACTIONS; BETA-KETO ACIDS; MULTICOMPONENT REACTIONS; DECARBOXYLATIVE ALKYLATION; CASCADE REACTIONS; NITROALKENES; DERIVATIVES;

D O I：

10.1080/00397911.2021.2024572

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The chiral 2-amino-4H-chromene derivatives were obtained from 2-alkyl-substituted phenol derivatives in moderate to high yields with excellent enantioselectivities through one-pot cascade via C-H oxidation/Michael addition/ring closure sequences using a binaphthyl-modified organocatalyst with low catalyst loading (1.25 mol%).

引用

页码：291 / 299

页数：9

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