Toxicity of propargylic alcohols on green alga-Pseudokirchneriella subcapitata

被引:14
作者
Chen, Chung Yuan [1 ]
Kuo, Kwan-Liang [1 ]
Fan, Je-Wei [1 ]
机构
[1] Natl Chiao Tung Univ, Inst Environm Engn, Hsinchu 300, Taiwan
来源
JOURNAL OF ENVIRONMENTAL MONITORING | 2012年 / 14卷 / 01期
关键词
INHIBITION; REACTIVITY;
D O I
10.1039/c1em10552c
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The present study evaluates the toxicity of 34 propargylic alcohols, including primary, primary homo-, secondary, and tertiary alcohols, based on their effects on phytoplankton. A closed-system algal toxicity test was applied because the closed-system technique presents more realistic concentration-response relationships for the above compounds than the conventional batch tests. The green alga, Pseudokirchneriella subcapitata, was the test organism and final yield and growth rate were chosen as the test endpoints. Among all the propargylic alcohols tested, 1-pentyn-3-ol is the most toxic compound with its EC50 equal to 0.50 mg L-1, which can be classified as a "R50" compound (very toxic to aquatic organisms, EC50/LC50 < 1 mg L-1), following the current practice for classification of chemicals in the European Union (EU). There are several other compounds including 2-decyn-1-ol, 3-decyn-1-ol, 1-hexyn-3-ol, 3-butyn-2-ol, and 3-hexyne-2,5-diol, which deserve more attention for their possible adverse impact on the aquatic environment, because these alcohols can be classified as "R51" compounds (toxic to aquatic organisms, EC50/LC50 between 1 and 10 mg L-1). Compared to the baseline toxicity relationship (narcosis QSAR) derived previously, tertiary propargylic alcohols can be identified as nonpolar narcotic chemicals, while secondary alcohols and primary alcohols with low molecular weight generally exhibit obvious excess toxicity in relation to the base-line toxicity. Finally, quantitative structure-activity relationships were established for deriving a preliminary estimation of the toxicity of other propargylic alcohols.
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页码:181 / 186
页数:6
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