Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety

被引：91
作者：
Snaidr, Victoria A. [1 ,2 ]
Damian, Diona L. [1 ,2 ,3 ]
Halliday, Gary M. [1 ,2 ]
机构：
[1] Univ Sydney, Bosch Inst, Discipline Dermatol, Sydney, NSW, Australia
[2] Royal Prince Alfred Hosp Sydney, Sydney, NSW, Australia
[3] Melanoma Inst Australia, Sydney, NSW, Australia
来源：
EXPERIMENTAL DERMATOLOGY | 2019年 / 28卷
关键词：
actinic keratosis; niacinamide; non-melanoma skin cancer; transplant patients; RADIATION-INDUCED IMMUNOSUPPRESSION; ORGAN TRANSPLANT RECIPIENTS; RANDOMIZED CONTROLLED-TRIAL; ULTRAVIOLET-RADIATION; DOUBLE-BLIND; TOPICAL NICOTINAMIDE; GENE-EXPRESSION; NIACIN; PREVENTION; HYPERPHOSPHATEMIA;
D O I：
10.1111/exd.13819
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Nicotinamide is a water-soluble vitamin B3 derivative that has many roles in medicine. This review examines the role of nicotinamide in dermatology and its actions in preventing photoageing and skin cancers in humans. Nicotinamide prevents ultraviolet radiation (UV) from reducing ATP levels and inhibiting glycolysis, thus preventing the UV radiation-induced energy crisis. This enhances DNA repair and reduces UV-induced suppression of immunity. Randomised controlled clinical trials have also shown that nicotinamide reduces transepidermal water loss and the development of new non-melanoma skin cancers in high-risk humans. This review also examines nicotinamide's safety profile.
引用
收藏
页码：15 / 22
页数：8
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