Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model

被引：639

作者：

Rockx, Barry ^{[1
]}

Kuiken, Thijs ^{[1
]}

Herfst, Sander ^{[1
]}

Bestebroer, Theo ^{[1
]}

Lamers, Mart M. ^{[1
]}

Munnink, Bas B. Oude ^{[1
]}

de Meulder, Dennis ^{[1
]}

van Amerongen, Geert ^{[2
]}

van den Brand, Judith ^{[1
,8
]}

Okba, Nisreen M. A. ^{[1
]}

Schipper, Debby ^{[1
]}

van Run, Peter ^{[1
]}

Leijten, Lonneke ^{[1
]}

Sikkema, Reina ^{[1
]}

Verschoor, Ernst ^{[3
]}

Verstrepen, Babs ^{[3
]}

Bogers, Willy ^{[3
]}

Langermans, Jan ^{[4
,5
]}

Drosten, Christian ^{[6
]}

van Vlissingen, Martje Fentener ^{[7
]}

Fouchier, Ron ^{[1
]}

de Swart, Rik ^{[1
]}

Koopmans, Marion ^{[1
]}

Haagmans, Bart L. ^{[1
]}

机构：

[1] Erasmus MC, Dept Virosci, Rotterdam, Netherlands

[2] Viroclin Xplore, Schaijk, Netherlands

[3] Biomed Primate Res Ctr, Dept Virol, Rijswijk, Netherlands

[4] Biomed Primate Res Ctr, Dept Anim Sci, Rijswijk, Netherlands

[5] Univ Utrecht, Unit Anim Sci & Soc, Populat Hlth Sci, Fac Vet Med, Utrecht, Netherlands

[6] Charite Univ Med Berlin, Inst Virol, Berlin, Germany

[7] Erasmus MC, Erasmus Lab Anim Sci Ctr, Rotterdam, Netherlands

[8] Univ Utrecht, Div Pathol, Fac Vet Med, Utrecht, Netherlands

来源：

SCIENCE | 2020年 / 368卷 / 6494期

基金：

欧盟地平线“2020”;

关键词：

SYNDROME CORONAVIRUS INFECTION; ACUTE RESPIRATORY SYNDROME; VIRAL LOAD; PNEUMONIA; OUTBREAK; LUNG;

D O I：

10.1126/science.abb7314

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The current pandemic coronavirus, severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), was recently identified in patients with an acute respiratory syndrome, coronavirus disease 2019 (COVID-19). To compare its pathogenesis with that of previously emerging coronaviruses, we inoculated cynomolgus macaques with SARS-CoV-2 or Middle East respiratory syndrome (MERS)-CoV and compared the pathology and virology with historical reports of SARS-CoV infections. In SARS-CoV-2-infected macaques, virus was excreted from nose and throat in the absence of clinical signs and detected in type I and II pneumocytes in foci of diffuse alveolar damage and in ciliated epithelial cells of nasal, bronchial, and bronchiolar mucosae. In SARS-CoV infection, lung lesions were typically more severe, whereas they were milder in MERS-CoV infection, where virus was detected mainly in type II pneumocytes. These data show that SARS-CoV-2 causes COVID-19-like disease in macaques and provides a new model to test preventive and therapeutic strategies.

引用

页码：1012 / +

页数：18

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