Effect of Acacia senegal on TGF-β1 and vascular mediators in a rat model of diabetic nephropathy

被引：8

作者：

Mohammed, Muataz E. ^{[1
]}

Abbas, Amr M. ^{[1
,2
]}

Badi, Rehab M. ^{[1
,3
]}

Bashir, Salah Omer ^{[1
]}

Osman, Osama M. ^{[1
]}

Morsy, Mohamed D. ^{[1
,4
]}

Saeed, Amal M. ^{[3
]}

机构：

[1] King Khalid Univ, Coll Med, Med Physiol Dept, Abha, Saudi Arabia

[2] Mansoura Univ, Coll Med, Med Physiol Dept, Mansoura, Egypt

[3] Khartoum Univ, Coll Med, Med Physiol Dept, Khartoum, Sudan

[4] Menoufia Univ, Coll Med, Med Physiol Dept, Al Minufya, Egypt

来源：

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY | 2022年 / 128卷 / 06期

关键词：

Gum Arabic; diabetic nephropathy; TGF-beta; 1; angiotensin II; endothelin-1; DENSITY-LIPOPROTEIN CHOLESTEROL; SOLUBLE DIETARY FIBER; PLASMA-CHOLESTEROL; GENE-EXPRESSION; MESANGIAL CELLS; GUM; GLUCOSE; FIBRONECTIN; ACTIVATION; KIDNEY;

D O I：

10.1080/13813455.2020.1781901

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Context:Transforming growth factor-beta 1 (TGF-beta 1), endothelin-1 and angiotensin II are responsible for extracellular matrix accumulation within the kidney in diabetic nephropathy. Objective:This study evaluated the effect of adding Gum Arabic (GA) and insulin on serum glucose, renal function, TGF-beta 1, endothelin-1, and angiotensin II in rats with diabetic nephropathy. Methods:Sixty male Sprague-Dawley rats were divided into; normal, normal plus GA, diabetic rats (DM), DM plus insulin, DM plus GA, and DM plus insulin plus GA groups. Levels of glucose and creatinine in serum, TGF-beta 1, angiotensin II, and endothelin-1 in renal homogenate and HbA1c were measured. Results:Serum creatinine, TGF-beta 1, angiotensin II, and endothelin-1 were increased in diabetic rats. GA decreased serum glucose, TGF-beta 1, angiotensin II, endothelin-1, and HbA1c in diabetic rats. GA and insulin decreased serum glucose, creatinine, TGF-beta 1, angiotensin II, endothelin-1, and HbA1c in diabetic rats. Conclusion:Co-administration of GA with insulin to rats with diabetic nephropathy improved the glycemic state, renal function, TGF-beta 1, endothelin-1, and angiotensin II.

引用

页码：1548 / 1558

页数：11