Effect of Acacia senegal on TGF-β1 and vascular mediators in a rat model of diabetic nephropathy

被引：8
|
作者：
Mohammed, Muataz E. [1 ]
Abbas, Amr M. [1 ,2 ]
Badi, Rehab M. [1 ,3 ]
Bashir, Salah Omer [1 ]
Osman, Osama M. [1 ]
Morsy, Mohamed D. [1 ,4 ]
Saeed, Amal M. [3 ]
机构：
[1] King Khalid Univ, Coll Med, Med Physiol Dept, Abha, Saudi Arabia
[2] Mansoura Univ, Coll Med, Med Physiol Dept, Mansoura, Egypt
[3] Khartoum Univ, Coll Med, Med Physiol Dept, Khartoum, Sudan
[4] Menoufia Univ, Coll Med, Med Physiol Dept, Al Minufya, Egypt
来源：
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY | 2022年 / 128卷 / 06期
关键词：
Gum Arabic; diabetic nephropathy; TGF-beta; 1; angiotensin II; endothelin-1; DENSITY-LIPOPROTEIN CHOLESTEROL; SOLUBLE DIETARY FIBER; PLASMA-CHOLESTEROL; GENE-EXPRESSION; MESANGIAL CELLS; GUM; GLUCOSE; FIBRONECTIN; ACTIVATION; KIDNEY;
D O I：
10.1080/13813455.2020.1781901
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Context:Transforming growth factor-beta 1 (TGF-beta 1), endothelin-1 and angiotensin II are responsible for extracellular matrix accumulation within the kidney in diabetic nephropathy. Objective:This study evaluated the effect of adding Gum Arabic (GA) and insulin on serum glucose, renal function, TGF-beta 1, endothelin-1, and angiotensin II in rats with diabetic nephropathy. Methods:Sixty male Sprague-Dawley rats were divided into; normal, normal plus GA, diabetic rats (DM), DM plus insulin, DM plus GA, and DM plus insulin plus GA groups. Levels of glucose and creatinine in serum, TGF-beta 1, angiotensin II, and endothelin-1 in renal homogenate and HbA1c were measured. Results:Serum creatinine, TGF-beta 1, angiotensin II, and endothelin-1 were increased in diabetic rats. GA decreased serum glucose, TGF-beta 1, angiotensin II, endothelin-1, and HbA1c in diabetic rats. GA and insulin decreased serum glucose, creatinine, TGF-beta 1, angiotensin II, endothelin-1, and HbA1c in diabetic rats. Conclusion:Co-administration of GA with insulin to rats with diabetic nephropathy improved the glycemic state, renal function, TGF-beta 1, endothelin-1, and angiotensin II.
引用
收藏
页码：1548 / 1558
页数：11
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