A New and Efficient Synthesis of 6-O-Methylscutellarein, the Major Metabolite of the Natural Medicine Scutellarin

被引：8

作者：

Zhang, Wei ^{[1
]}

Dong, Ze-Xi ^{[1
]}

Gu, Ting ^{[1
]}

Li, Nian-Guang ^{[1
]}

Zhang, Peng-Xuan ^{[1
]}

Wu, Wen-Yu ^{[1
]}

Yu, Shao-Peng ^{[1
]}

Tang, Yu-Ping ^{[1
]}

Yang, Jian-Ping ^{[1
]}

Shi, Zhi-Hao ^{[2
]}

机构：

[1] Nanjing Univ Chinese Med, Natl & Local Collaborat Engn Ctr Chinese Med Reso, Nanjing 210023, Jiangsu, Peoples R China

[2] China Pharmaceut Univ, Dept Organ Chem, Nanjing 211198, Jiangsu, Peoples R China

来源：

MOLECULES | 2015年 / 20卷 / 06期

基金：

中国国家自然科学基金;

关键词：

scutellarin; scutellarein; 6-O-methylscutellarein; metabolite; synthesis; NITRIC-OXIDE; IN-VIVO; THROMBIN; DESIGN; 6-O-METHYL-SCUTELLAREIN; ISCHEMIA/REPERFUSION; RATS;

D O I：

10.3390/molecules200610184

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this paper, a new and efficient synthesis of 6-O-methylscutellarein (3), the major metabolite of the natural medicine scutellarin, is reported. Two hydroxyl groups at C-4 and C-7 in 2 were selectively protected by chloromethyl methyl ether after the reaction conditions were optimized, then 6-O-methyl-scutellarein (3) was produced in high yield after methylation of the hydroxyl group at C-6 and subsequent deprotection of the two methyl ether groups.

引用

页码：10184 / 10191

页数：8

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