Genetic transformation of a Corynebacterial symbiont from the Chagas disease vector Triatoma infestans

被引：52

作者：

Durvasula, Ravi V. ^{[1
]}

Sundaram, Ranjini K. ^{[1
]}

Kirsch, Philipp ^{[3
]}

Hurwitz, Ivy ^{[1
]}

Crawford, Carl V. ^{[1
]}

Dotson, Ellen ^{[2
]}

Beard, Charles B. ^{[4
]}

机构：

[1] Univ New Mexico, Dept Internal Med, Albuquerque, NM 87131 USA

[2] CDC, Natl Ctr Infect Dis, Div Parasit Dis, Chamblee, GA USA

[3] APTIV Inc, Portland, OR USA

[4] Ctr Dis Control & Prevent, Ft Collins, CO USA

来源：

EXPERIMENTAL PARASITOLOGY | 2008年 / 119卷 / 01期

关键词：

paratransgenesis; chagas disease; Triatoma infestans; corynebacteria;

D O I：

10.1016/j.exppara.2007.12.020

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Insect-borne diseases have experienced a troubling resurgence in recent years. Emergence of resistance to pesticides greatly hampers control efforts. Paratransgenesis, or the genetic transformation of bacterial symbionts of disease vectors, is an alternative to traditional approaches. Previously, we developed paratransgenic lines of Rhodniusprolixus, a vector of Chagas disease in Central America. Here, we report identification of a Corynebacterial species as a symbiont of Triatoma infestans, a leading vector of Chagas disease in South America. We have modified this bacterium to produce an immunologically active single chain antibody fragment, termed rDB3. This study establishes the basis for generating paratransgenic T infestans as a strategy for control of Chagas disease. Published by Elsevier Inc.

引用

页码：94 / 98

页数：5

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