One Month of Oral Morphine Decreases Gray Matter Volume in the Right Amygdala of Individuals with Low Back Pain: Confirmation of Previously Reported Magnetic Resonance Imaging Results

被引:35
作者
Lin, Joanne C. [1 ]
Chu, Larry F. [2 ]
Stringer, Elizabeth Ann [2 ]
Baker, Katharine S. [3 ]
Sayyid, Zahra N. [2 ]
Sun, John [2 ]
Campbell, Kelsey A. [1 ]
Younger, Jarred W. [1 ]
机构
[1] Univ Alabama Birmingham, Dept Psychol, 233 Campbell Hall,1300 Univ Blvd, Birmingham, AL 35294 USA
[2] Stanford Univ, Sch Med, Dept Anesthesia, Stanford, CA 94305 USA
[3] Monash Univ, Sch Psychol Sci, Clayton, Vic 3800, Australia
关键词
Opioids; Magnetic Resonance Imaging; Tensor-Based Morphometry; FUNCTIONAL CONNECTIVITY; BASOLATERAL AMYGDALA; HUMAN-BRAIN; REWARD; CORTEX; NEUROBIOLOGY; MECHANISMS; DISORDERS; THERAPY; SYSTEM;
D O I
10.1093/pm/pnv047
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Objective. Prolonged exposure to opioids is known to produce neuroplastic changes in animals; however, few studies have investigated the effects of short-term prescription opioid use in humans. A previous study from our laboratory demonstrated a dosage-correlated volumetric decrease in the right amygdala of participants administered oral morphine daily for 1 month. The purpose of this current study was to replicate and extend the initial findings. Methods. Twenty-one participants with chronic low back pain were enrolled in this double-blind, placebo-controlled study. Participants were randomized to receive daily morphine (n = 11) or a matched placebo (n = 10) for 1 month. High-resolution anatomical images were acquired immediately before and after the treatment administration period. Morphological gray matter changes were investigated using tensor-based morphometry, and significant regions were subsequently tested for correlation with morphine dosage. Results. Decreased gray matter volume was observed in several reward- and pain-related regions in the morphine group, including the bilateral amygdala, left inferior orbitofrontal cortex, and bilateral pre-supplementary motor areas. Morphine administration was also associated with significant gray matter increases in cingulate regions, including the mid cingulate, dorsal anterior cingulate, and ventral posterior cingulate. Conclusions. Many of the volumetric increases and decreases overlapped spatially with the previously reported changes. Individuals taking placebo for 1 month showed neither gray matter increases nor decreases. The results corroborate previous reports that rapid alterations occur in reward-related networks following short-term prescription opioid use.
引用
收藏
页码:1497 / 1504
页数:8
相关论文
共 35 条
[1]   Cytoarchitectonic mapping of the human amygdala, hippocampal region and entorhinal cortex: intersubject variability and probability maps [J].
Amunts, K ;
Kedo, O ;
Kindler, M ;
Pieperhoff, P ;
Mohlberg, H ;
Shah, NJ ;
Habel, U ;
Schneider, F ;
Zilles, K .
ANATOMY AND EMBRYOLOGY, 2005, 210 (5-6) :343-352
[2]  
Ashburner J, 2000, HUM BRAIN MAPP, V9, P212, DOI 10.1002/(SICI)1097-0193(200004)9:4<212::AID-HBM3>3.0.CO
[3]  
2-#
[4]   A fast diffeomorphic image registration algorithm [J].
Ashburner, John .
NEUROIMAGE, 2007, 38 (01) :95-113
[5]   Opioid therapy for chronic pain [J].
Ballantyne, JC ;
Mao, JR .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (20) :1943-1953
[6]   High opiate receptor binding potential in the human lateral pain system [J].
Baumgärtner, U ;
Buchholz, HG ;
Bellosevich, A ;
Magerl, W ;
Siessmeier, T ;
Rolke, R ;
Höhnemann, S ;
Piel, M ;
Rösch, F ;
Wester, HJ ;
Henriksen, GJN ;
Stoeter, P ;
Bartenstein, P ;
Treede, RD ;
Schreckenberger, M .
NEUROIMAGE, 2006, 30 (03) :692-699
[7]   Reward-aversion circuitry in analgesia and pain: Implications for psychiatric disorders [J].
Borsook, David ;
Becerra, Lino ;
Carlezon, William A., Jr. ;
Shaw, Marnie ;
Renshaw, Perry ;
Elman, Igor ;
Levine, Jon .
EUROPEAN JOURNAL OF PAIN, 2007, 11 (01) :7-20
[8]   The neurobiology and genetics of impulse control disorders: Relationships to drug addictions [J].
Brewer, Judson A. ;
Potenza, Marc N. .
BIOCHEMICAL PHARMACOLOGY, 2008, 75 (01) :63-75
[9]   Opioid tolerance and hyperalgesia in chronic pain patients after one month of oral morphine therapy: A preliminary prospective study [J].
Chu, LF ;
Clark, DJ ;
Angst, MS .
JOURNAL OF PAIN, 2006, 7 (01) :43-48
[10]  
Cleeland C. S., 1994, Annals Academy of Medicine Singapore, V23, P129