Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases

被引：131

作者：

Van Rompay, AR

Johansson, M

Karlsson, A

机构：

[1] Huddinge Univ Hosp, Karolinska Inst, Div Clin Virol, S-14186 Huddinge, Sweden

[2] Univ Instelling Antwerp, Div Nephrol Hypertens, B-2610 Antwerp, Belgium

来源：

PHARMACOLOGY & THERAPEUTICS | 2003年 / 100卷 / 02期

关键词：

antiviral therapy; anticancer therapy; chemotherapy; nucleoside analogue; deoxyribonucleoside kinase; ribonucleoside kinase;

D O I：

10.1016/j.pharmthera.2003.07.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Structural analogues of nucleosides, nucleoside analogues (NA), are used in the treatment of cancer and viral infections. Antiviral NAs inhibit replication of the viral genome, whereas anticancer NAs inhibit cellular DNA replication and repair. NAs are inactive prodrugs that are dependent on intracellular phosphorylation to their pharmacologically active triphosphate form. The deoxyribonucleoside kinases (dNK) and ribonucleoside kinases (rNK) catalyze the first phosphorylation step, converting deoxyribonucleosides and ribonucleosides to their corresponding monophosphate form. The dNKs have been studied intensively, whereas the rNKs have not been as thoroughly investigated. This overview is focused on the substrate specificity, tissue distribution, and subcellular location of the mammalian dNKs and rNKs and their role in the activation of NAs. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：119 / 139

页数：21

共 229 条

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