High stability of blood parameters during mouse lifespan: sex-specific effects of every-other-day fasting

被引：6

作者：

Bayliak, Maria M. ^{[1
]}

Sorochynska, Oksana M. ^{[1
]}

Kuzniak, Oksana V. ^{[1
]}

Drohomyretska, Ivanna Z. ^{[1
]}

Klonovskyi, Andriy Ya. ^{[1
]}

Hrushchenko, Anastasia O. ^{[1
]}

Vatashchuk, Myroslava V. ^{[1
]}

Mosiichuk, Nadia M. ^{[1
]}

Storey, Kenneth B. ^{[2
]}

Garaschuk, Olga ^{[3
]}

Lushchak, Volodymyr I. ^{[1
,4
]}

机构：

[1] Vasyl Stefanyk Precarpathian Natl Univ, Dept Biochem & Biotechnol, 57 Shevchenko Str, UA-76018 Ivano Frankivsk, Ukraine

[2] Carleton Univ, Dept Biol, 1125 Colonel Dr, Ottawa, ON K1S 5B6, Canada

[3] Univ Tubingen, Inst Physiol, Dept Neurophysiol, D-72074 Tubingen, Germany

[4] Res & Dev Univ, 13a Shota Rustaveli Str, UA-76018 Ivano Frankivsk, Ukraine

来源：

BIOGERONTOLOGY | 2022年 / 23卷 / 05期

关键词：

Aging; Hematology; Every-other-day fasting; Blood biochemistry; Leucocytes; LACTATE; STRESS; ENERGY; BRAIN; YOUNG; RESPONSES; AGE;

D O I：

10.1007/s10522-022-09982-x

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Every-other-day fasting (EODF) is one type of caloric restriction that is proposed to have significant health benefits, including slowing aging-related processes. The present study evaluated multiple parameters of blood homeostasis comparing mice of different ages and mice on different diet regimes: ad libitum (AL) versus EODF. Hematological and classical biochemical parameters of blood were measured in young (6-month), middle-aged (12-month) and old (18-month) C57BL/6J mice of both sexes subjected either to EODF, or AL feeding. Middle-aged AL males showed a decrease in erythrocyte and total leucocyte counts and an increase in plasma alkaline phosphatase activity, whereas old animals showed a decrease in relative levels of lymphocytes and an increase in relative levels of neutrophils, a decrease in plasma lactate and an increase in total cholesterol levels, compared to young mice. AL-fed females demonstrated higher stability of blood parameters during aging than males did. The EODF regimen did not significantly affect hematological parameters in females but prevented a decline in total leukocyte count with age in males. In both sexes, EODF partially prevented age-associated changes in levels of plasma lactate and cholesterol and activity of alkaline phosphatase. Thus, during normal aging, mice showed a sex-dependent maintenance of blood homeostasis which was not significantly affected by EODF.

引用

页码：559 / 570

页数：12

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