Nanostructure-Dependent Ratiometric NIR Fluorescence Enabled by Ordered Dye Aggregation

被引:10
作者
Charron, Danielle M. [1 ,2 ,3 ]
Chen, Juan [1 ,2 ]
Zheng, Gang [1 ,2 ,3 ,4 ]
机构
[1] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada
[2] Univ Hlth Network, Techna Inst, Toronto, ON, Canada
[3] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON, Canada
[4] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada
来源
CHEMNANOMAT | 2016年 / 2卷 / 05期
基金
加拿大创新基金会; 加拿大健康研究院; 加拿大自然科学与工程研究理事会;
关键词
aggregation; drug delivery; imaging agents; nanoparticles; self-assembly; DRUG-DELIVERY; MULTIFUNCTIONAL NANOPARTICLES; SCAVENGER RECEPTOR; QUANTUM-DOT; PRECISION MEDICINE; CLASS-B; SR-BI; CANCER; THERAPY; CHALLENGES;
D O I
10.1002/cnma.201600038
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Nanocarriers incorporating therapeutic and imaging agents within a single nanostructure are emerging tools for drug development and treatment planning. Additional information can be provided using activatable fluorescence that dynamically reports nanocarrier disruption and drug release. Dual-wavelength activation encodes a unique fluorescence signal for each nanocarrier state, enabling use of ratiometric imaging to measure the proportion of intact and disrupted nanocarriers within tissues. Here we investigate dual-wavelength activation using a single dye whose optical properties are intricately linked to the nanocarrier structure. Natural bacteriochlorophyll incorporated within a compact lipoprotein nanocarrier forms ordered dye aggregates with red-shifted fluorescence emission from 765 nm to 825 nm. We demonstrate that bacteriochlorophyll-ordered aggregation is a feasible strategy to distinguish intact and disrupted theranostic nanocarriers by ratiometric fluorescence imaging.
引用
收藏
页码:430 / 436
页数:7
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