Host cell targets for antiviral therapy:: an update

The discovery of antiviral therpeutic targets has traditionally focussed on conserved viral gene products. Since viruses are obligate molecular parasites requiring and manipulating host cell functions, the identification of host proteins essential to viruses but not cellular survival represent attractive and underutilized targets for antiviral therapies. Numerous studies have identified host cell functions, pathways and proteins that are essential for viral propagation, from entry to replication, assembly and egress. Importantly, several studies demonstrate virus inhibition through nonlethal impairment of host cell function both in vitro and in vivo. In addition, high-throughput experimental platforms allowing global or nearglobal surveillance of host gene products in the context of virus replication are now being used to systematically identify host cell targets. Recent breakthrough studies that have employed such methods successfully to identify host proteins and pathways crucial for virus growth are discussed in this review.