Predictors of survival in dementia with Lewy bodies and Parkinson dementia

被引：55

作者：

Jellinger, Kurt A.

Wenning, Gregor K.

Seppi, Klaus

机构：

[1] Inst Clin Neurobiol, A-1070 Vienna, Austria

[2] Innsbruck Med Univ, Dept Neurol, Innsbruck, Austria

来源：

NEURODEGENERATIVE DISEASES | 2007年 / 4卷 / 06期

关键词：

dementia with Lewy bodies; Parkinson disease with dementia; predictors; survival; fluctuating cognition; Alzheimer pathology;

D O I：

10.1159/000107703

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Retrospective analysis of 243 autopsy-confirmed cases of dementia with Lewy bodies (DLB) and Parkinson disease with dementia (PDD) showed an average age at symptom onset of 67 years and a median survival of 5 years from symptom onset. Older age at onset, fluctuating cognition, and hallucinations at onset predicted shorter survival; initial parkinsonism with delayed dementia significantly improved survival. Associated Alzheimer pathology also shortened survival. When adjusted for age, gender, and Alzheimer pathology, fluctuating dementia at symptom onset was identified as best predictor of poor outcome. Copyright (c) 2007 S. Karger AG, Basel.

引用

页码：428 / 430

页数：3

共 12 条

[1] Differences in neuropathologic characteristics across the Lewy body dementia spectrum [J].

Ballard, C. ;

Ziabreva, I. ;

Perry, R. ;

Larsen, J. P. ;

O'Brien, J. ;

McKeith, I. ;

Perry, E. ;

Aarsland, D. .

NEUROLOGY, 2006, 67 (11) :1931-1934

[2] AN EXAMINATION OF MALE-FEMALE DIFFERENCES IN PROGRESSION AND MORTALITY OF PARKINSONS-DISEASE [J].

DIAMOND, SG ;

MARKHAM, CH ;

HOEHN, MM ;

MCDOWELL, FH ;

MUENTER, MD .

NEUROLOGY, 1990, 40 (05) :763-766

[3] Prevalence of vascular lesions in dementia with Lewy bodies. A postmortem study [J].

Jellinger, KA .

JOURNAL OF NEURAL TRANSMISSION, 2003, 110 (07) :771-778

[4] Impact of coexistent Alzheimer pathology on the natural history of Parkinson's disease [J].

Jellinger, KA ;

Seppi, K ;

Wenning, GK ;

Poewe, W .

JOURNAL OF NEURAL TRANSMISSION, 2002, 109 (03) :329-339

[5] Presynaptic α-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies [J].

Kramer, Michael L. ;

Schulz-Schaeffer, Walter J. .

JOURNAL OF NEUROSCIENCE, 2007, 27 (06) :1405-1410

[6] DLB and PDD boundary issues - Diagnosis, treatment, molecular pathology, and biomarkers [J].

Lippa, C. F. ;

Duda, J. E. ;

Grossman, M. ;

Hurtig, H. I. ;

Aarsland, D. ;

Boeve, B. F. ;

Brooks, D. J. ;

Dickson, D. W. ;

Dubois, B. ;

Emre, M. ;

Fahn, S. ;

Farmer, J. M. ;

Galasko, D. ;

Galvin, J. E. ;

Goetz, C. G. ;

Growdon, J. H. ;

Gwinn-Hardy, K. A. ;

Hardy, J. ;

Heutink, P. ;

Iwatsubo, T. ;

Kosaka, K. ;

Lee, V. M. -Y. ;

Leverenz, J. B. ;

Masliah, E. ;

McKeith, I. G. ;

Nussbaum, R. L. ;

Olanow, C. W. ;

Ravina, B. M. ;

Singleton, A. B. ;

Tanner, C. M. ;

Trojanowski, J. Q. ;

Wszolek, Z. K. .

NEUROLOGY, 2007, 68 (11) :812-819

[7] Natural history of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) and clinical predictors of survival: A clinicopathological study [J].

Litvan, I ;

Mangone, CA ;

McKee, A ;

Verny, M ;

Parsa, A ;

Jellinger, K ;

DOlhaberriague, L ;

Chaudhuri, KR ;

Pearce, RKB .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1996, 60 (06) :615-620

[8] Diagnosis and management of dementia with Lewy bodies - Third report of the DLB consortium [J].

McKeith, IG ;

Dickson, DW ;

Lowe, J ;

Emre, M ;

O'Brien, JT ;

Feldman, H ;

Cummings, J ;

Duda, JE ;

Lippa, C ;

Perry, EK ;

Aarsland, D ;

Arai, H ;

Ballard, CG ;

Boeve, B ;

Burn, DJ ;

Costa, D ;

Del Ser, T ;

Dubois, B ;

Galasko, D ;

Gauthier, S ;

Goetz, CG ;

Gomez-Tortosa, E ;

Halliday, G ;

Hansen, LA ;

Hardy, J ;

Iwatsubo, T ;

Kalaria, RN ;

Kaufer, D ;

Kenny, RA ;

Korczyn, A ;

Kosaka, K ;

Lee, VMY ;

Lees, A ;

Litvan, I ;

Londos, E ;

Lopez, OL ;

Minoshima, S ;

Mizuno, Y ;

Molina, JA ;

Mukaetova-Ladinska, EB ;

Pasquier, F ;

Perry, RH ;

Schulz, JB ;

Trojanowski, JQ ;

Yamada, M .

NEUROLOGY, 2005, 65 (12) :1863-1872

[9] Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop [J].

McKeith, IG ;

Galasko, D ;

Kosaka, K ;

Perry, EK ;

Dickson, DW ;

Hansen, LA ;

Salmon, DP ;

Lowe, J ;

MIrra, SS ;

Byrne, EJ ;

Lennox, G ;

Quinn, NP ;

Edwardson, JA ;

Ince, PG ;

Bergeron, C ;

Burns, A ;

Miller, BL ;

Lovestone, S ;

Collerton, D ;

Jansen, ENH ;

Ballard, C ;

deVos, RAI ;

Wilcock, GK ;

Jellinger, KA ;

Perry, RH .

NEUROLOGY, 1996, 47 (05) :1113-1124

[10] Influence of Alzheimer pathology on clinical diagnostic accuracy in dementia with Lewy bodies [J].

Merdes, AR ;

Hansen, LA ;

Jeste, DV ;

Galasko, D ;

Hofstetter, CR ;

Ho, GJ ;

Thal, LJ ;

Corey-Bloom, J .

NEUROLOGY, 2003, 60 (10) :1586-1590

← 1 2 →