Effect of Adjuvant Chemotherapy on Survival of Elderly Patients With Stage III Colorectal Cancer

被引：11

作者：

Shibutani, Masatsune ^{[1
]}

Maeda, Kiyoshi ^{[2
]}

Kashiwagi, Shinichiro ^{[3
]}

Hirakawa, Kosei ^{[1
]}

Ohira, Masaichi ^{[1
]}

机构：

[1] Osaka City Univ, Grad Sch Med, Dept Gastroenterol Surg, Osaka, Japan

[2] Osaka City Gen Hosp, Dept Gastroenterol Surg, Osaka, Japan

[3] Osaka City Univ, Grad Sch Med, Dept Breast & Endocrine Surg, Osaka, Japan

来源：

ANTICANCER RESEARCH | 2021年 / 41卷 / 07期

关键词：

Colorectal cancer; stage III colorectal cancer; adjuvant chemotherapy; FLUOROURACIL PLUS LEUCOVORIN; COLON-CANCER; POOLED ANALYSIS; BOLUS FLUOROURACIL; CONTROLLED-TRIAL; ORAL LEUCOVORIN; URACIL-TEGAFUR; OXALIPLATIN; THERAPY; AGE;

D O I：

10.21873/anticanres.15150

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: The aim of this study was to investigate the efficacy and safety of adjuvant chemotherapy in elderly patients with stage III colorectal cancer in a real world setting. Patients and Methods: A total of 165 patients of >= 70 years of age with stage III colorectal cancer who underwent a curative operation between 2008 and 2020 were enrolled in this study. Results: Among septuagenarians, the relapse-free and overall survival rates in the single-agent therapy group and the combination therapy group were significantly better than those in the group treated by surgery alone. However, no significant differences were observed in the relapse-free and overall survival rates of the single-agent therapy group and the combination therapy group. Among octogenarians in whom all regimens were single-agent therapy, adjuvant chemotherapy tended to improve the relapse-free and overall survival rates but not the time to recurrence or cancer-specific survival. Conclusion: Single agent adjuvant chemotherapy may be a useful treatment option for septuagenarians with stage III colorectal cancer. However, the efficacy of adjuvant chemotherapy in octogenarians was not shown in this study.

引用

页码：3615 / 3624

页数：10

共 33 条

[1] Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer [J].

Andre, T ;

Boni, C ;

Mounedji-Boudiaf, L ;

Navarro, M ;

Tabernero, J ;

Hickish, T ;

Topham, C ;

Zaninelli, M ;

Clingan, P ;

Bridgewater, J ;

Tabah-Fisch, I ;

de Gramont, A .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (23) :2343-2351

[2] NCCN Guidelines® Insights Colon Cancer, Version 2.2018 Featured Updates to the NCCN Guidelines [J].

Benson, Al B., III ;

Venook, Alan P. ;

Al-Hawary, Mahmoud M. ;

Cederquist, Lynette ;

Chen, Yi-Jen ;

Ciombor, Kristen K. ;

Cohen, Stacey ;

Cooper, Harry S. ;

Deming, Dustin ;

Engstrom, Paul F. ;

Garrido-Laguna, Ignacio ;

Grem, Jean L. ;

Grothey, Axel ;

Hochster, Howard S. ;

Hoffe, Sarah ;

Hunt, Steven ;

Kamel, Ahmed ;

Kirilcuk, Natalie ;

Krishnamurthi, Smitha ;

Messersmith, Wells A. ;

Meyerhardt, Jeffrey ;

Miller, Eric D. ;

Mulcahy, Mary F. ;

Murphy, James D. ;

Nurkin, Steven ;

Saltz, Leonard ;

Sharma, Sunil ;

Shibata, David ;

Skibber, John M. ;

Sofocleous, Constantinos T. ;

Stoffel, Elena M. ;

Stotsky-Himelfarb, Eden ;

Willett, Christopher G. ;

Wuthrick, Evan ;

Gregory, Kristina M. ;

Freedman-Cass, Deborah A. .

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2018, 16 (04) :359-369

[3] Randomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer [J].

Carmichael, J ;

Popiela, T ;

Radstone, D ;

Falk, S ;

Borner, M ;

Oza, A ;

Skovsgaard, T ;

Munier, S ;

Martin, C .

JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (17) :3617-3627

[4] Bevacizumab plus capecitabine versus capecitabine alone in elderly patients with previously untreated metastatic colorectal cancer (AVEX): an open-label, randomised phase 3 trial [J].

Cunningham, David ;

Lang, Istvan ;

Marcuello, Eugenio ;

Lorusso, Vito ;

Ocvirk, Janja ;

Shin, Dong Bok ;

Jonker, Derek ;

Osborne, Stuart ;

Andre, Niko ;

Waterkamp, Daniel ;

Saunders, Mark P. .

LANCET ONCOLOGY, 2013, 14 (11) :1077-1085

[5] Adjuvant Chemotherapy in Elderly Colorectal Cancer Patients [J].

Glimelius, Bengt ;

Osterman, Erik .

CANCERS, 2020, 12 (08) :1-22

[6] Randomized controlled trial of reduced-dose bolus fluorouracil plus leucovorin and irinotecan or infused fluorouracil plus leucovorin and oxaliplatin in patients with previously untreated metastatic colorectal cancer: A North American intergroup trial [J].

Goldberg, Richard M. ;

Sargent, Daniel J. ;

Morton, Roscoe F. ;

Fuchs, Charles S. ;

Ramanathan, Ramesh K. ;

Williamson, Stephen K. ;

Findlay, Brian P. ;

Pitot, Henry C. ;

Alberts, Steven .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (21) :3347-3353

[7] Impact of age and medical comorbidity on adjuvant treatment outcomes for stage III colon cancer: a pooled analysis of individual patient data from four randomized, controlled trials [J].

Haller, D. G. ;

O'Connell, M. J. ;

Cartwright, T. H. ;

Twelves, C. J. ;

McKenna, E. F. ;

Sun, W. ;

Saif, M. W. ;

Lee, S. ;

Yothers, G. ;

Schmoll, H. -J. .

ANNALS OF ONCOLOGY, 2015, 26 (04) :715-724

[8] Capecitabine Plus Oxaliplatin Compared With Fluorouracil and Folinic Acid As Adjuvant Therapy for Stage III Colon Cancer [J].

Haller, Daniel G. ;

Tabernero, Josep ;

Maroun, Jean ;

de Braud, Filippo ;

Price, Timothy ;

Van Cutsem, Eric ;

Hill, Mark ;

Gilberg, Frank ;

Rittweger, Karen ;

Schmoll, Hans-Joachim .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (11) :1465-1471

[9] Final results of randomized trials by the National Surgical Adjuvant Study of Colorectal Cancer (NSAS-CC) [J].

Hamaguchi, Tetsuya ;

Shirao, Kuniaki ;

Moriya, Yoshihiro ;

Yoshida, Shigeaki ;

Kodaira, Susumu ;

Ohashi, Yasuo .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2011, 67 (03) :587-596

[10] Japanese Society for Cancer of the Colon and Rectum (JS']JSCCR) guidelines 2019 for the treatment of colorectal cancer [J].

Hashiguchi, Yojiro ;

Muro, Kei ;

Saito, Yutaka ;

Ito, Yoshinori ;

Ajioka, Yoichi ;

Hamaguchi, Tetsuya ;

Hasegawa, Kiyoshi ;

Hotta, Kinichi ;

Ishida, Hideyuki ;

Ishiguro, Megumi ;

Ishihara, Soichiro ;

Kanemitsu, Yukihide ;

Kinugasa, Yusuke ;

Murofushi, Keiko ;

Nakajima, Takako Eguchi ;

Oka, Shiro ;

Tanaka, Toshiaki ;

Taniguchi, Hiroya ;

Tsuji, Akihito ;

Uehara, Keisuke ;

Ueno, Hideki ;

Yamanaka, Takeharu ;

Yamazaki, Kentaro ;

Yoshida, Masahiro ;

Yoshino, Takayuki ;

Itabashi, Michio ;

Sakamaki, Kentaro ;

Sano, Keiji ;

Shimada, Yasuhiro ;

Tanaka, Shinji ;

Uetake, Hiroyuki ;

Yamaguchi, Shigeki ;

Yamaguchi, Naohiko ;

Kobayashi, Hirotoshi ;

Matsuda, Keiji ;

Kotake, Kenjiro ;

Sugihara, Kenichi .

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2020, 25 (01) :1-42

← 1 2 3 4 →