Oligomeganephronia: Case Report and Literature Review

被引:4
作者
Yang, Xiang-dong [1 ]
Shi, Weiwei [1 ]
Li, Dengren [1 ]
Peng, Tao [1 ]
机构
[1] Shandong Univ, Dept Nephrol, Qilu Hosp, Jinan 250012, Peoples R China
关键词
oligomeganephronia; renal pathology; diagnosis; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; RENAL HYPOPLASIA; OLIGONEPHROPATHY; PROTEINURIA; MUTATIONS; OBESITY; GENE;
D O I
10.2298/SARH1412732Y
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction Oligomeganephronia (OMN) is one of rare congenital kidney disease. The number of nephrons reduces and the volume of glomerulus increases. The incidence of OMN is uncertain because it is difficult to diagnose. There are no any special clinical manifestations of OMN. Renal pathology is the only way to diagnose OMN, so missed diagnosis always happens without renal pathology. Case Outline A 26-year-old male was diagnosed OMN associated with proteinuria and increased serum creatinine. The size of both kidneys on ultrasound was smaller than normal. Pathological features involved a reduced number of greatly enlarged glomeruli indicating OMN. Conclusion OMN is a rare disease and it has been rarely reported. The exact mechanism is not clear. The diagnosis mainly depends on pathological findings. For patients with OMN, proteinuria and renal dysfunction are often the main cause to visit a doctor. Early diagnosis is important.
引用
收藏
页码:732 / 735
页数:4
相关论文
共 25 条
[1]  
Abdelraheem Mohamed, 2004, Saudi J Kidney Dis Transpl, V15, P53
[2]   Risk Factors for the Development of Diabetic Nephropathy [J].
Antic, Miodrag ;
Jotic, Aleksandra ;
Radovic, Milan ;
Seferovic, Jelena P. ;
Lalic, Nebojsa M. ;
Jovanovic, Dijana ;
Lezaic, Visnja .
SRPSKI ARHIV ZA CELOKUPNO LEKARSTVO, 2009, 137 (1-2) :18-26
[3]  
BERTHOUX FC, 1978, J UROL NEPHROL, V84, P872
[4]   Distinct molecular and morphogenetic properties of mutations in the human HNF1β gene that lead to defective kidney development [J].
Bohn, S ;
Thomas, H ;
Turan, G ;
Ellard, S ;
Bingham, C ;
Hattersley, AT ;
Ryffel, GU .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2003, 14 (08) :2033-2041
[5]  
Bondar IA, 2011, TERAPEVT ARKH, V83, P66
[6]  
Broyer M, 1997, Adv Nephrol Necker Hosp, V26, P47
[7]   Focal Segmental Glomerulosclerosis [J].
D'Agati, Vivette D. ;
Kaskel, Frederick J. ;
Falk, Ronald J. .
NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (25) :2398-2411
[8]  
Drukker A, 2002, ISRAEL MED ASSOC J, V4, P191
[9]  
HABIB R, 1962, J Urol Nephrol (Paris), V68, P139
[10]   Focal segmental glomerulosclerosis plays a major role in the progression of IgA nephropathy. I. Immunohistochemical studies [J].
Hill, Gary S. ;
El Karoui, Khalil ;
Karras, Alexandre ;
Mandet, Chantal ;
Van Huyen, Jean-Paul Duong ;
Nochy, Dominique ;
Bruneval, Patrick .
KIDNEY INTERNATIONAL, 2011, 79 (06) :635-642