PhFl acetic acid: A new linker for solid phase organic synthesis

被引：12

作者：

Bleicher, KH ^{[1
]}

Wareing, JR ^{[1
]}

机构：

[1] Nova Pharmaceut Corp, E Hanover, NJ 07936 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 26期

关键词：

D O I：

10.1016/S0040-4039(98)00846-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A 9-phenylfluoren-9-yl based linker for the immobilization of nitrogen and oxygen nucleophiles is described. Improved acid stability compared to the com,non trityl linker is demonstrated by a quantitative method for analysis of loading, This new linker is used for the synthesis of a peptide alcohol in the 'inverse' direction via reduction of the corresponding N linked peptide methyl ester. Several other nucleophiles are immobilized and further modified. TFA treatment releases the corresponding products in high purity. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：4591 / 4594

页数：4

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