Inhibition of acetylcholinesterase activity by bicyclic monoterpenoids

被引：153

作者：

Miyazawa, M ^{[1
]}

Yamafuji, C ^{[1
]}

机构：

[1] Kinki Univ, Dept Appl Chem, Fac Sci & Engn, Higashiosaka, Osaka 5778502, Japan

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2005年 / 53卷 / 05期

关键词：

acetylcholinesterase; bicyclic monoterpenoids; inhibition of enzyme activity; uncompetitive inhibitor;

D O I：

10.1021/jf040019b

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Inhibition of acetylcholinesterase (AChE) activity by 17 kinds of bicyclic monoterpenoids was investigated. Bicyclic monoterpenoids are contained in many kinds of essential oils. Inhibition of AChE was measured according to the colorimetric method. 3.1.1 and 4.1.0 bicyclic hydrocarbons with allylic methyl group showed strong inhibition. (+)- and (-)-alpha-pinene and (+)-3-carene were potent inhibitors of AChE. 3.1.1 and 2.2.1 bicyclic alcohols and ketones showed weak inhibition. 3.1.1 and 4.1.0 bicyclic hydrocarbons with allylic methyl group were found to be uncompetitive inhibitors.

引用

页码：1765 / 1768

页数：4

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