Controlled Zn2+-Triggered Drug Release by Preferred Coordination of Open Active Sites within Functionalization Indium Metal Organic Frameworks

被引：62

作者：

Du, Xi ^{[1
]}

Fan, Ruiqing ^{[1
]}

Qiang, Liangsheng ^{[1
]}

Xing, Kai ^{[1
]}

Ye, Haoxin ^{[1
]}

Ran, Xinya ^{[1
]}

Song, Yang ^{[1
]}

Wang, Ping ^{[1
]}

Yang, Yulin ^{[1
]}

机构：

[1] Harbin Inst Technol, MIIT Key Lab Crit Mat Technol New Energy Convers, Sch Chem & Chem Engn, Harbin 150001, Heilongjiang, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2017年 / 9卷 / 34期

基金：

中国国家自然科学基金;

关键词：

preferred coordination strategy; open active sites; host-guest interaction; nano-MOFs; Zn2+-triggered drug release; PHASE-TRANSITION; GAS-ADSORPTION; SINGLE-CRYSTAL; NANOPARTICLES; ENCAPSULATION; VALIDATION; CATALYSTS; WATER;

D O I：

10.1021/acsami.7b09227

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Drug delivery in target regions could make extraordinary progress in chemoselective therapies. A novel preferred coordination (PC) strategy referring to proactive interacting with open active sites to replace previous occupation by ion-exchange for controlling release of drug molecules is well-constructed. Two topological types of MOF-In1 (Schlafli symbol: (4,8)-connected of (4(10).6(15).8(3))(4(5).6)(2)) and MOF-In2 (Schlafli symbol: (4,4)-connected of (6(6))) show the specific way. Increasing node connectivity as well as the trapping of guest OH- anions, 5-fluorouracil (5-FU) is preferentially captured into the MOF-In1, which exhibits an outstanding loading capacity around 34.32 wt %. F-19 NMR spectroscopy was further employed to investigate host-guest interaction and reveal the binding constant (K-a = 3.84 X 10(2) M-1). Meanwhile, the controlled release of 5-FU in a simulated human body with liquid phosphate-buffered saline solution by biofriendly Zn2+-triggered is realized. With an elevated Zn2+ concentration, the drug release will be enhanced. This efficient strategy for MOFs as multifunctional drug carrier opens a new avenue for biological and medical applications.

引用

页码：28939 / 28948

页数：10

共 56 条

[1] Multifunctional Mesoporous Silica Nanoparticles as a Universal Platform for Drug Delivery [J].