Direct synthesis of pyridine derivatives

被引：342

作者：

Movassaghi, Mohammad ^{[1
]}

Hill, Matthew D. ^{[1
]}

Ahmad, Omar K. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 33期

关键词：

D O I：

10.1021/ja073912a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe a single-step conversion of various N-vinyl and N-aryl amides to the corresponding pyridine and quinoline derivatives, respectively. The process involves amide activation with trifluoromethanesulfonic anhydride in the presence of 2-chloropyridine followed by pi-nucleophile addition to the activated intermediate and annulation. Compatibility of this chemistry with sensitive N-vinyl amides, epimerizable substrates, and a variety of functional groups is noteworthy.

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页码：10096 / +

页数：3

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